R
Reto A. Schwendener
Researcher at University of Zurich
Publications - 172
Citations - 12645
Reto A. Schwendener is an academic researcher from University of Zurich. The author has contributed to research in topics: Liposome & Cytotoxic T cell. The author has an hindex of 55, co-authored 171 publications receiving 11423 citations. Previous affiliations of Reto A. Schwendener include École Polytechnique Fédérale de Lausanne & Paul Scherrer Institute.
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Journal ArticleDOI
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
Slava Epelman,Kory J. Lavine,Anna E. Beaudin,Dorothy K. Sojka,Javier A. Carrero,Boris Calderon,Thaddeus Brija,Emmanuel L. Gautier,Stoyan Ivanov,Ansuman T. Satpathy,Joel D. Schilling,Reto A. Schwendener,Ismail Sergin,Babak Razani,E. Camilla Forsberg,Wayne M. Yokoyama,Emil R. Unanue,Marco Colonna,Gwendalyn J. Randolph,Douglas L. Mann +19 more
TL;DR: Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis, and the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size.
Journal ArticleDOI
Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach.
Steffen M. Zeisberger,Bernhard Odermatt,Cornelia Marty,A H M Zehnder-Fjällman,Kurt Ballmer-Hofer,Reto A. Schwendener,Reto A. Schwendener +6 more
TL;DR: Clodrolip therapy in combination with angiogenesis inhibitors as a promising novel strategy for an indirect cancer therapy aimed at the haematopoietic precursor cells that stimulate tumour growth and dissemination and as a tool to study the role of macrophages and dendritic cells in tumorigenesis are validated.
Journal ArticleDOI
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
Edy Y. Kim,John T. Battaile,Anand C. Patel,Yingjian You,Eugene Agapov,Mitchell H. Grayson,Loralyn A. Benoit,Derek E. Byers,Yael G. Alevy,Jennifer Tucker,Suzanne Swanson,Rose M. Tidwell,Jeffrey W. Tyner,Jeffrey D. Morton,Mario Castro,Deepika Polineni,G. Alexander Patterson,Reto A. Schwendener,John Allard,Gary Peltz,Michael J. Holtzman +20 more
TL;DR: It is found that this type of disease arises independently of an adaptive immune response and is driven instead by interleukin-13 produced by macrophages that have been stimulated by CD1d-dependent T cell receptor–invariant natural killer T (NKT) cells.
Journal ArticleDOI
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance
Yun Sok Lee,Pingping Li,Jin Young Huh,In Jae Hwang,Min Lu,Jong In Kim,Mira Ham,Saswata Talukdar,Ai Chen,Wendell J. Lu,Guatam K. Bandyopadhyay,Reto A. Schwendener,Jerrold M. Olefsky,Jae Bum Kim +13 more
TL;DR: Data suggest that the initial stage of HFD-induced insulin resistance is independent of inflammation, whereas the more chronic state of insulin resistance in established obesity is largely mediated by macrophage-induced proinflammatory actions.
Journal ArticleDOI
Antennapedia and HIV Transactivator of Transcription (TAT) “Protein Transduction Domains” Promote Endocytosis of High Molecular Weight Cargo upon Binding to Cell Surface Glycosaminoglycans
Sandra Console,Cornelia Marty,Carlos Garcia-Echeverria,Reto A. Schwendener,Kurt Ballmer-Hofer +4 more
TL;DR: The data reported here support the idea that certain PTDs promote cellular uptake via endocytosis and require the expression of negatively charged glycosaminoglycans on the surface of the target cells, and support the view that PTD-mediated cellular uptake is energy-independent.