Patent
Method for producing a sustained release formulation
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TLDR
In this article, a method for preparing a sustained release formulation with collagen and gelatin as a carrier is described, which comprises the steps of: (i) preparing a uniform and high concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and or gelatin, and water or an admixture consisting of water and a hydro-philic organic solvent under one of the conditions selected from: (ii) the pH of the mixture is kept below 5 and the salt concentration of a mixture is retained below fiber-forming concentration; (iii) chemically modifiedAbstract:
Described is a method for preparing a sustained release formulation utiliing collagen and/or gelatin as a carrier, which comprises the steps:
(i) preparing a uniform and high concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture consisting of water and a hydrophilic organic solvent under one of the conditions selected from:
(A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration; (B) chemically modified collagen and/or gelatin is employed; and (C) glucose is added to the mixture; (ii) molding the resultant mixture; and (iii) gradually eliminating the solvent from the molded product.read more
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