V
Vicki Rosen
Researcher at Harvard University
Publications - 160
Citations - 22396
Vicki Rosen is an academic researcher from Harvard University. The author has contributed to research in topics: Bone morphogenetic protein & Bone morphogenetic protein 2. The author has an hindex of 58, co-authored 154 publications receiving 21257 citations. Previous affiliations of Vicki Rosen include United States Department of Agriculture & University of California, Los Angeles.
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Journal ArticleDOI
Novel regulators of bone formation: molecular clones and activities.
John M. Wozney,Vicki Rosen,Anthony J. Celeste,Lisa M. Mitsock,Matthew J. Whitters,Ronald W. Kriz,Rodney M. Hewick,Elizabeth A. Wang +7 more
TL;DR: Human complementary DNA clones corresponding to three polypeptides present in this BMP preparation have been isolated, and expression of the recombinant human proteins have been obtained, and each appears to be independently capable of inducing the formation of cartilage in vivo.
Journal ArticleDOI
Recombinant human bone morphogenetic protein induces bone formation.
Elizabeth A. Wang,Vicki Rosen,Josephine S. D'alessandro,M Bauduy,Paul Cordes,T Harada,David I. Israel,Rodney M. Hewick,K M Kerns,P LaPan +9 more
TL;DR: The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts, and has therapeutic potential to promote de novo bone formation in humans.
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Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone
Anthony J. Celeste,James A. Iannazzi,Robin C. Taylor,Rodney M. Hewick,Vicki Rosen,Elizabeth A. Wang,John M. Wozney +6 more
TL;DR: Three human bone morphogenetic proteins show extensive sequence similarity to BMP-2, a molecule that by itself is sufficient to induce de novo bone formation in vivo and is strongly implicated by the presence of these growth factors in the most active fractions of highly purified bone extract.
Journal ArticleDOI
Novel Regulators of Bone Formation: Molecular Clones and Activities
John M. Wozney,Vicki Rosen,Anthony J. Celeste,Lisa M. Mitsock,Matthew J. Whitters,Ronald W. Kriz,Rodney M. Hewick,Elizabeth A. Wang +7 more
TL;DR: Human complementary DNA clones corresponding to three polypeptides present in this BMP preparation have been isolated, and expression of the recombinant human proteins have been obtained, and each appears to be independently capable of inducing the formation of cartilage in vivo.
Journal ArticleDOI
Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments
Ronen Schweitzer,Jay H. Chyung,Lewis C. Murtaugh,Ava E. Brent,Vicki Rosen,Eric N. Olson,Andrew B. Lassar,Clifford J. Tabin +7 more
TL;DR: Scleraxis, a bHLH transcription factor, is a highly specific marker for all the connective tissues that mediate attachment of muscle to bone in chick and mouse, including the limb tendons, and it is shown that early scleraxis expression marks the progenitor cell populations for these tissues.