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Methods and device for detecting and quantifying substances in body fluids

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TLDR
An in vivo method and apparatus for detecting an analyte in an individual was proposed in this article. But, the method required the individual to be in contact with a sensor that was configured to retain the fluorescence reagent while allowing analyte to diffuse into and out of the sensor.
Abstract
An in vivo method and apparatus for detecting an analyte in an individual. A sensor that includes a fluorescence reagent is placed in communication with the body fluids of the individual suspected of containing the analyte in such a way that once in place said sensor does not exit the skin of the individual. The sensor is configured to retain the fluorescence reagent while allowing analyte to diffuse into and out of said sensor. The sensor is illuminated transdermally, and the fluorescence from the fluorescence reagent associated with the presence of the analyte is measured.

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Citations
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References
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Journal ArticleDOI

Detection of nucleic acid hybridization by nonradiative fluorescence resonance energy transfer

TL;DR: The results establish that fluorescence modulation and nonradiative fluorescence resonance energy transfer can detect nucleic acid hybridization in solution and these techniques, with further development, may also prove useful for detecting and quantifying nucleic acids Hybridization in living cells.
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