Microbial transformation of antibiotics
TLDR
Streptomyces sp.Abstract:
Streptomyces sp. strain No. K-245 was found to transform maridomycin III into four derivatives (A1, A2, A3 and A4) in addition to the transformation products reported previously. Isolation of the main product A1 was carried out by column chromatography on silica gel developed with CHCl3-MeOH (19:1). From the partial investigation of the structure of A1 it proved to have a C 18-aldehyde group and C 4"-propionyl group but no antimicrobial activity. The relationships between A group's derivatives and known derivatives of maridomycin III are also discussed.read more
Citations
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The beta-lactam antibiotics: past, present, and future.
TL;DR: The β-lactam group of compounds are the most successful example of natural product application and chemotherapy and continued efforts have resulted in the improvement of these compounds with respect to potency, breadth of spectrum, activity against resistant pathogens, stability and pharmacokinetic properties.
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A New Resistance Gene, linB, Conferring Resistance to Lincosamides by Nucleotidylation in Enterococcus faecium HM1025
Bülent Bozdogan,Latifa Berrezouga,Ming-Shang Kuo,David A. Yurek,Kathleen A. Farley,Brian J. Stockman,Roland Leclercq,Roland Leclercq +7 more
TL;DR: Resistance to lincomycin and clindamycin in the clinical isolateEnterococcus faecium HM1025 is due to a ribosomal methylase encoded by an ermAM-like gene and the plasmid-mediated inactivation of these antibiotics.
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Comparative aspects of development and differentiation in actinomycetes.
L V Kalakoutskii,N S Agre +1 more
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New lnu(C) Gene Conferring Resistance to Lincomycin by Nucleotidylation in Streptococcus agalactiae UCN36
TL;DR: Streptococcus agalactiae UCN36 was resistant to lincomycin but susceptible to clindamycin and erythromycin, and mass spectrometry experiments demonstrated that the LnuC enzyme catalyzed adenylylation of lincomYcin.
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Makrolide. Neuere Fortschritte ihrer Chemie und Biochemie
TL;DR: In den letten Jahren haben sich Chemie und Biochemie der Makrolide eindrucksvoll weiterentwickelt. In as discussed by the authors, die wesentlichen Arbeiten auf den Gebieten der Strukturermittlung, der chemischen Synthese, der biochemie, der antimikrobiellen Aktivitat vor allem the Polyoxomakrolid-Antibiotica zusammenzufassen.
References
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TL;DR: The actinomycetes represent a widely distributed group of organisms which comprise many forms possessing marked antagonistic properties against bacteria, fungi and other microorganisms, and streptothricin was selected for further study because of its low toxicity, as well as its selective action against gram-negative and gram-positive bacteria.
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Relationship of structures and microbiological activities of the 16-membered macrolides.
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Studies on antibiotic sf-733, a new antibiotic. ii
TL;DR: In this paper, the site of linkage was determined by the formation of di-N-acetyl-6-O-methyl-2-deoxystreptamine after acid hydrolysis of tetra-N -acetyl -hexa-O -methyl SF-733 and it was concluded that the ribofuranosyl linkage was β.