Journal ArticleDOI
Mixed Connective Tissue Disease: A Clinicopathologic Study of 20 Cases
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This article is published in Seminars in Arthritis and Rheumatism.The article was published on 1980-08-01. It has received 132 citations till now. The article focuses on the topics: Mixed connective tissue disease.read more
Citations
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Book ChapterDOI
Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.
TL;DR: Autoantibodies to nuclear antigens (ANAs) have assumed an important place in the diagnostic armamentarium of the clinician because of distinct profiles of ANAs in different diseases.
Journal ArticleDOI
Mixed connective tissue disease: to be or not to be?
Josef S. Smolen,Günter Steiner +1 more
Journal ArticleDOI
Cardiovascular manifestations of mixed connective tissue disease in adults.
Martin A. Alpert,S H Goldberg,B H Singsen,J B Durham,G C Sharp,Masood Ahmad,N P Madigan,D P Hurst,W D Sullivan +8 more
TL;DR: Cardiovascular abnormalities associated with mixed connective tissue disease include acute pericarditis and/or effusion, mitral valve prolapse, intimal hyperplasia of coronary arteries, perivascular and myocardial leukocytic infiltrates, and pulmonary hypertension.
Journal ArticleDOI
Mixed connective tissue disease: An overview of clinical manifestations, diagnosis and treatment
TL;DR: There is no full agreement about treatment and the initial impression of a satisfactory response to low doses of steroids is not always the rule, but available evidence is reviewed to a better approach to all previous topics.
Journal ArticleDOI
Mixed connective tissue disease
TL;DR: The recent advances in therapy and the current understanding of prognosis and prognostic factors are discussed, especially those that are associated with the more serious pulmonary and cardiovascular complications of the disease.
References
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Journal ArticleDOI
Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)
TL;DR: The detection of antibody to ENA with a well defined specificity allows recognition of an apparently distinct mixed connective tissue disease syndrome which is characterized by an excellent response to corticosteroid therapy and a favorable prognosis.
Journal ArticleDOI
Isolation of pure and unaltered liver nuclei morphology and biochemical composition.
TL;DR: It is shown that the contamination of the nuclei by cytoplasmic structures is one of the main difficulties encountered in the isolation of the nuclear fraction and an accurate count of contaminants is necessary, especially in the study of thenuclear composition.
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Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls
TL;DR: The organs found to be frequently and significantly involved by systemic sclerosis were the skin, gastrointestinal tract, lungs, kidneys, skeletal muscle and pericardium, and atrophy was usually a more prominent finding than was fibrosis in organs containing smooth muscle.
Journal ArticleDOI