Patent
Multi-channel microfluidic system design with balanced fluid flow distribution
TLDR
In this paper, the authors present a method and apparatus for controlling fluid flow with pressure gradient fluid control, where passive fluid flow barriers are used to act as valves, thereby allowing the flow of fluids through flow paths to be regulated so as to allow fluids to be introduced via a single channel and subsequently split into multiple channels.Abstract:
Methods and apparatus are presented for controlling fluid flow with pressure gradient fluid control. Passive fluid flow barriers may be used to act as valves, thereby allowing the flow of fluids through flow paths to be regulated so as to allow fluids to be introduced via a single channel (50) and subsequently split into multiple channels (58, 60). Flow through flow paths can be regulated to allow a series of sister wells (51-53) or chambers to all fill prior to the fluid flowing beyond any one of the sister wells (51-53) or chambers. Each flow path may have multiple segments (66-69), at least one of which is designed to balance the pressure drops of the flow paths to provide uniform flow of fluids through the flow paths. The configurations of the wells (51-53) may be modified by adding vents or flow dividers to enhance fluid flushing and gas removal capability.read more
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Patent
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TL;DR: In this paper, the authors present a system for microfluidic manipulation and analysis of particles, such as cells, viruses, organelles, beads, and vesicles.
Patent
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Patent
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Chemical amplification based on fluid partitioning
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References
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Patent
Integrated nucleic acid diagnostic device
TL;DR: In this paper, a miniaturized integrated nucleic acid diagnostic device and system is presented, which can perform one or more sample acquisition and preparation operations, in combination with one or multiple sample analysis operations.
Patent
High throughput screening assay systems in microscale fluidic devices
TL;DR: In this paper, the authors present novel microfluidic devices and methods that are useful for performing high-throughput screening assays for a variety of chemical and biochemical systems.
Patent
Capillary flow device
Robert S. Hillman,Michael E. Cobb,Jimmy D Allen,Ian Gibbons,Vladimir E Ostoich,Laura J. Winfrey +5 more
TL;DR: In this paper, a fabrication technique particularly suited for forming internal chambers in plastic devices is described along with various control devices for use with the device, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering.
Patent
Mesoscale polynucleotide amplification devices
Peter Wilding,Larry J. Kricka +1 more
TL;DR: In this paper, a polynucleotide amplification reaction chamber with a high surface-to-volume ratio (SVR) is proposed to amplify a preselected polynotide in a sample.
Patent
Mesoscale polynucleotide amplification device and method
Peter Wilding,Larry J. Kricka +1 more
TL;DR: In this article, the mesoscale flow system includes a polynucleotide polymerization reaction chamber in fluid communication with the inlet port which is provided with reagents required for polymerization and amplification of a preselected polynotide.