Anthony J. Makarewicz

TL;DR: A high-throughput droplet digital PCR system that enables processing of ∼2 million PCR reactions using conventional TaqMan assays with a 96-well plate workflow is described that will allow researchers to explore complex genetic landscapes, discover and validate new disease associations, and define a new era of molecular diagnostics.

TL;DR: A microfluidics-based, linked-read sequencing technology that can phase and haplotypes generated from whole-genome sequencing of a primary colorectal adenocarcinoma and cancer genomes using nanograms of input DNA is presented.

TL;DR: In this article, the authors present a system for separating sample components by partitioning them into droplets or other partitions, amplifying or reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.

TL;DR: In this article, an open end of a channel network may be placed into an emulsion and droplets of the emulsion may be driven along a flow path from the open end, through a confluence region where a dilution fluid is introduced into the flowpath from at least one dilution inlet channel to increase an average distance between droplets, and through an examination region disposed downstream of the confluence regions.

TL;DR: In this article, a well and a channel component attached to the well are configured to receive sample-containing fluid in the well and retain the sample containing fluid below a top end of the passage, until a pressure differential is created that drives at least a portion of the samplecontaining fluid from the well via the passage and through the microchannel.