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Darren R. Link
Researcher at Harvard University
Publications - 92
Citations - 17109
Darren R. Link is an academic researcher from Harvard University. The author has contributed to research in topics: Liquid crystal & Digital polymerase chain reaction. The author has an hindex of 50, co-authored 92 publications receiving 16151 citations. Previous affiliations of Darren R. Link include University of Colorado Boulder & University of California, Santa Barbara.
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Journal ArticleDOI
Monodisperse Double Emulsions Generated from a Microcapillary Device
Andrew S. Utada,Elise Lorenceau,Darren R. Link,Peter D. Kaplan,Howard A. Stone,David A. Weitz +5 more
TL;DR: It is shown that the droplet size can be quantitatively predicted from the flow profiles of the fluids, which makes this a flexible and promising technique.
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Droplet microfluidic technology for single-cell high-throughput screening
Eric Brouzes,Martina Medkova,Neal Savenelli,Dave Marran,Mariusz Twardowski,J. Brian Hutchison,Jonathan M. Rothberg,Darren R. Link,Norbert Perrimon,Michael L. Samuels +9 more
TL;DR: The droplet microfluidic platform is modular, robust, uses no moving parts, and has a wide range of potential applications including high-throughput single-cell analyses, combinatorial screening, and facilitating small sample analyses.
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Geometrically Mediated Breakup of Drops in Microfluidic Devices
TL;DR: Two methods for passively breaking larger drops into precisely controlled daughter drops using pressure-driven flow in simple microfluidic configurations using a T junction and flow past isolated obstacles are demonstrated.
Journal ArticleDOI
Spontaneous formation of macroscopic chiral domains in a fluid smectic phase of achiral molecules
Darren R. Link,Giorgio Natale,Renfan Shao,Joseph E. Maclennan,Noel A. Clark,Eva Korblova,David M. Walba +6 more
TL;DR: A smectic liquid-crystal phase made from achiral molecules with bent cores was found to have fluid layers that exhibit two spontaneous symmetry-breaking instabilities: polar molecular orientational ordering about the layer normal and molecular tilt.
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Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity
Jean-Christophe Baret,Oliver J. Miller,Valérie Taly,Michael Ryckelynck,Abdeslam El-Harrak,Lucas Frenz,Christian Rick,Michael L. Samuels,J. Brian Hutchison,Jeremy J. Agresti,Darren R. Link,David A. Weitz,Andrew D. Griffiths +12 more
TL;DR: A theoretical model based on the Poisson distribution accurately predicted the observed enrichment values using the starting cell density (cells per droplet) and the ratio of active to inactive cells, and all of the recovered cells were the active strain.