Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera
TLDR
Multilayered amniotic membrane transplantation may be effective for the treatment of deep ulceration of the cornea and sclera in some eyes with total corneal limbal dysfunction or autoimmune disorders.About:
This article is published in American Journal of Ophthalmology.The article was published on 2001-03-01 and is currently open access. It has received 240 citations till now. The article focuses on the topics: corneal ulcer & Corneal perforation.read more
Citations
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The amniotic membrane in ophthalmology
TL;DR: The reintroduction of amniotic membrane in ophthalmic surgery holds great promise; however, although it has been shown to be a useful and viable alternative for some conditions, it is currently being used far in excess of its true useful potential.
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Naturally occurring scaffolds for soft tissue repair and regeneration.
TL;DR: Cell growth supports (i.e., scaffolds) that provide a conducive environment for normal cellular growth, differentiation, and angiogenesis are important components of tissue engineered grafts because rapid integration with the host is essential for long-term graft viability.
Journal ArticleDOI
Human amniotic membrane transplantation: Different modalities of its use in ophthalmology.
Chintan Malhotra,Arun K Jain +1 more
TL;DR: The amniotic membrane is being used increasingly for ocular surface reconstruction in a variety of ocular pathologies including corneal disorders associated with limbal stem cell deficiency, surgeries for conjunctival reconstruction, as a carrier for ex vivo expansion of limbal epithelial cells, glaucoma surgeries and sceral melts and perforations.
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Immunosuppressive factors secreted by human amniotic epithelial cells.
Haochuan Li,Jerry Y. Niederkorn,Sudha Neelam,Elizabeth Mayhew,R. Ann Word,James P. McCulley,Hassan Alizadeh +6 more
TL;DR: Whether amniotic epithelial cells secrete anti-inflammatory and antiproliferative factors that affect the chemotaxis of neutrophils and macrophages and suppress both T- and B-cell proliferation in vitro is determined.
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Amniotic membrane grafts for nontraumatic corneal perforations, descemetoceles, and deep ulcers
Abraham Solomon,Daniel Meller,Pinnita Prabhasawat,Thomas John,E.M. Espana,Klaus-Peter Steuhl,Scheffer C.G. Tseng,Scheffer C.G. Tseng +7 more
TL;DR: AMT is an effective method for managing nontraumatic corneal perforations and descemetoceles and can serve as either a permanent therapy or as a temporizing measure until the inflammation has subsided and a definitive reconstructive procedure can be performed.
References
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Amniotic Membrane Transplantation With or Without Limbal Allografts for Corneal Surface Reconstruction in Patients With Limbal Stem Cell Deficiency
TL;DR: For partial limbal deficiency with superficial involvement, AMT alone is sufficient and hence superior to ALT because there is no need to administer cyclosporine, and AMT helps reconstruct the perilimbal stroma, with reduced inflammation and vascularization, which collectively may enhance the success of ALT.
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Transplantation of Preserved Human Amniotic Membrane for Surface Reconstruction in Severely Damaged Rabbit Corneas
Jae Chan Kim,Scheffer C.G. Tseng +1 more
TL;DR: The results suggest that measures taken to facilitate epithelialization without allowing host fibrovascular ingrowth onto the amniotic membrane might prove this procedure clinically useful for ocular surface reconstruction.
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Amniotic membrane transplantation for persistent epithelial defects with ulceration.
TL;DR: Amniotic membrane transplantation may be considered an alternative method for treating persistent epithelial defects and sterile ulceration that are refractory to conventional treatment and before considering treatment by conjunctival flaps or tarsorrhaphy.
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Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome.
Kazuo Tsubota,Kazuo Tsubota,Yoshiyuki Satake,Mitsuko Ohyama,Ikuko Toda,Ikuko Toda,Yoji Takano,Yoji Takano,Masafumi Ono,Masafumi Ono,Naoshi Shinozaki,Jun Shimazaki +11 more
TL;DR: Although in this study the follow-up period was short and relatively few patients were studied, this approach appears to offer an alternative to keratoprosthesis for treating severe cicatricial keratoconjunctivitis with dry eye.
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Cytologic evidence of corneal diseases with limbal stem cell deficiency
TL;DR: Impression cytology can be used to diagnose and monitor corneal diseases with limbal deficiency, which manifest distinct clinical problems and are generally poor candidates for penetrating keratoplasty.
Related Papers (5)
Transplantation of Preserved Human Amniotic Membrane for Surface Reconstruction in Severely Damaged Rabbit Corneas
Jae Chan Kim,Scheffer C.G. Tseng +1 more