Journal ArticleDOI
Mutagenic action of mitomycin C on Escherichia coli.
Teiji Iijima,Atsuyoshi Hagiwara +1 more
TLDR
MITOMYCIN C is of biological interest not only because it selectively inhibits cellular deoxyribonucleic acid synthesis1,2 but also in that it induces lambda phage development in Escherichia coli K 123.Abstract:
MITOMYCIN C is of biological interest not only because it selectively inhibits cellular deoxyribonucleic acid synthesis1,2 but also in that it induces lambda phage development in Escherichia coli K 123.read more
Citations
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Book ChapterDOI
The Mutagenicity of Chemical Carcinogens: Correlations, Problems, and Interpretations
TL;DR: It is not known at the molecular level how any chemical carcinogen induces the formation of cells which are not responsive to the growth controls of the host and which form neoplasms that grow more or less continuously and may invade normal tissues.
Journal ArticleDOI
The induction of mitotic recombination by mitomycin c in ustilago and saccharomyces.
TL;DR: It is shown that the antibiotic mitomycin C stimulates mitotic crossing over in Ustilago with an efficiency comparable to that of UV, and furthermore, that it does not appear to have mutagenic activity under the same conditions of treatment.
Book ChapterDOI
Mechanisms of resistance to anticancer agents.
TL;DR: This chapter focuses on mechanisms of resistance to anticancer agents, including mechanisms of action of the inhibitors under discussion, and discusses nucleic acid synthesis, glutamine antagonists and purine analogs.
Journal ArticleDOI
Bacteriocidal action of mitomycin C.
TL;DR: The bacteriocidal action of Mitomycin C has been investigated with respect to its biochemical, genetic and morphological correlates as discussed by the authors, and the results were consistent with the observation that cells treated with the drug lose DNA, but not RNA or protein, to the surrounding medium.
Journal ArticleDOI
Mitomycin c: chemical and biological studies on alkylation.
TL;DR: It is proposed that mitomycin is activated in vivo, possibly by a reduction which "unmasks" the potential activity of the fused aziridine ring.
References
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Journal ArticleDOI
Induction of phage formation in the lysogenic Escherichia coli K-12 by mitomycin C.
TL;DR: This communication concerns the lytic process of Escherichia coli K–12 induced by mitomycin C added externally, and suggests that this antibiotic could induce the development of active phage from the prophage state in lysogenic bacteria, since they are similar to ultra-violet effects.
Journal ArticleDOI
Selective inhibition of formation of deoxyribonucleic acid in Escherichia coli by mitomycin C.
TL;DR: Investigation of the mechanism of the actions of mitomycin C obtained evidence that this antibiotic selectively inhibits the synthesis of deoxyribonucleic acid in Escherichia coli B.
Journal ArticleDOI
Synthesis of deoxyribonucleic acid by phage-infected Escherichia coli in presence of mitomycin C.
Mutsuo Sekiguchi,Yasuyuki Takagi +1 more
TL;DR: This communication shows that the impaired synthesis of deoxyribonucleic acid in cells treated with mitomycin C can be promptly restored by infection with bacteriophage T2r.
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Induction of phage formation in the lysogenic Escherichia coli K-12 by mitomycin C.
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A molecular mechanism of mitomycin action: linking of complementary dna strands.
V. N. Iyer,Waclaw Szybalski +1 more