Journal ArticleDOI
Myospherulosis: a preventable iatrogenic nasal and paranasal entity.
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TLDR
It is recommended that a nonpetrolatum-based substance be used in nasal packing for purposes of hemostasis because both components of the vehicle of a commonly used tetracycline antibiotic ointment, lanolin and petrolatum produce the structures of myospherulosis in vitro.Abstract:
We discuss a disorder that, although at first considered of possible fungal origin, now is known to be due to an alteration of erythrocytes induced by petrolatum-based antibiotic ointment. In this country, the structures of myospherulosis have been seen most often in tissues from the nose and paranasal sinuses following surgery in this region. Our studies show that both components of the vehicle of a commonly used tetracycline antibiotic ointment, lanolin and petrolatum, either separately or together, produce the structures of myospherulosis in vitro. It is recommended that a nonpetrolatum-based substance be used in nasal packing for purposes of hemostasis.read more
Citations
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Journal ArticleDOI
Nasal packing after routine nasal surgery—is it justified?
TL;DR: Routine nasal packing, especially with BIPP, would seen difficult to justify in view of the increased pain levels and increased complications which occur without any demonstrable benefit in the majority of patients, therefore packing should be reserved for cases where there is concern about persistent haemorrhage.
Journal ArticleDOI
Packing in endonasal surgery
TL;DR: In view of the present lack of standardization and the many different packing materials used, the currently available materials are reviewed and their respective properties, indications, and risks are outlined.
Journal ArticleDOI
Pharmaceutical excipients. Adverse effects associated with inactive ingredients in drug products (Part I).
TL;DR: It is highly recommended that all pharmaceutical manufacturers list all their excipients and make this available to practitioners and drug information centres, as well as enabling susceptible patients to avoid inadvertent exposure.
Journal ArticleDOI
A giant pyogenic granuloma in the nasal cavity caused by nasal packing
TL;DR: This is the third case recorded in the literature of a confirmed pyogenic granuloma occuring as a complication of nasal packing, and this uncommon lesion should be considered in the differential diagnosis of a rapidly growing hemorrhagic lesion within the nasal fossa.
Journal ArticleDOI
Current status of topical nasal antimicrobial agents.
Yau Hong Goh,Richard L. Goode +1 more
TL;DR: The anatomical and physiological factors that should be considered in the use of topical nasal antimicrobial agents and the current status of topical facial antimicrobial usage are reviewed, and recommendations are made for the administration of topical saline-based antimicrobials.
References
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Journal ArticleDOI
Myospherulosis of the paranasal sinuses, nose and middle ear. A possible iatrogenic disease.
TL;DR: Sixteen cases of myospherulosis, a disease of unknown etiology previously reported only from East Africa, were found in the St. Louis metropolitan area, and a common denominator in these cases was the operative use of hemostatic packing containing petrolatum-based ointments and gauze.
Journal ArticleDOI
The nature of myospherulosis of the upper respiratory tract.
TL;DR: A case of myospherulosis of paranasal sinuses similar in appearance to those recently seen in St. Louis, Missouri, was examined to ascertain the nature of the sac-like structures seen in this disease, and morphologic features suggest that they represent collections of erythrocytes altered by a foreign substance.
Journal ArticleDOI
Myospherulosis: a previously unreported disease?
Journal Article
The induction of human myospherulosis in experimental animals.
TL;DR: Experimental evidence strongly suggests that the structures of myospherulosis can be iatrogenically produced by the use of petrolatum-based antibiotic ointments.