Open AccessJournal Article
Narcotic blockade. 1966.
V P Dole,M E Nyswander,M J Kreek +2 more
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This article is published in Journal of Psychoactive Drugs.The article was published on 1991-04-01 and is currently open access. It has received 66 citations till now. The article focuses on the topics: Narcotic & Historical Article.read more
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Stress, Dysregulation of Drug Reward Pathways, and the Transition to Drug Dependence
George F. Koob,Mary Jeanne Kreek +1 more
TL;DR: A model of the role of different levels of hormonal/brain stress activation in addiction is presented that has heuristic value for understanding individual vulnerability to drug dependence and novel treatments for the disorder.
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Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure.
TL;DR: The reinstatement model has adequate criterion validity in the broad sense of the term, as evidenced by the fact that reinstatement in laboratory animals is induced by conditions reported to provoke relapse in humans.
Journal Article
The Role of Corticotropin-Releasing Factor in Drug Addiction
TL;DR: The goal of this article is to summarize available data examining the physiological significance of brain corticotropin-releasing factor systems in mediating the behavioral and physiological effects of several classes of abused drugs, including opioid and psychostimulant drugs, alcohol and sedative hypnotics, nicotine, and cannabinoids.
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1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial.
TL;DR: The combination of buprenorphine and intensive psychosocial treatment is safe and highly efficacious, and should be added to the treatment options available for individuals who are dependent on heroin.
Journal ArticleDOI
Methadone maintenance at different dosages for opioid dependence.
TL;DR: Methadone dosages ranging from 60 to 100 mg/day are more effective than lower dosages in retaining patients and in reducing use of heroin and cocaine during treatment.
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A Medical Treatment for Diacetylmorphine (Heroin) Addiction: A Clinical Trial With Methadone Hydrochloride
Vincent P. Dole,Marie Nyswander +1 more