Journal ArticleDOI
Natural Mode of Acquisition for de Novo Infection with Pneumocystis carinii
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TLDR
Findings show that P. carinii is naturally acquired as an airborne organism in a de novo infection.Abstract:
Axenic rats maintained in germfree isolators were found to be free of Pneumocystis carinii after three months of immunosuppression with dexamethasone. This P. carinii-free rat model was used to identify the mode of acquisition of P. carinii from the natural environment. Germfree were exposed in selective manner to potential sources of P.carinii, including air, water, and food. Animals exposed in the isolator with filtered (sterile) air and to regular (unsterile) water and food did not acquire P. carinii. Rats exposed in open cages to room air but maintained on sterile water and food acquired the infection. Animals fed lung tissue infected with P. carinii did not acquire the infection. These findings show that P. carinii is naturally acquired as an airborne organism in a de novo infection.read more
Citations
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Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC)
TL;DR: This report reviews previous guidelines and strategies for preventing environment-associated infections in health-care facilities and offers recommendations, including evidence-based recommendations supported by studies and experienced opinions based upon infection-control and engineering practices.
Journal Article
Guidelines for environmental infection control in health-care facilities. Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC).
TL;DR: A review of previous guidelines and strategies for preventing environment-associated infections in health-care facilities and offers recommendations can be found in this article, where the authors suggest a series of performance measurements as a means to evaluate infection-control efforts.
Journal ArticleDOI
Medical progress: Pneumocystis pneumonia
TL;DR: Advances that have resulted from studies of the cell biology, biochemistry, and genetics of pneumocystis in the past several years are summarized and recommendations for the diagnosis and treatment are included, as well as for prophylaxis and treatment.
Journal ArticleDOI
Pneumocystis carinii Pneumonia
TL;DR: For example, by the middle of the 20th century, Pneumocystis carinii pneumonitis had not been recognized in North America as mentioned in this paper. Yet within the past two decades the prevalence has increased to the point that several...
Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and HIV-Infected Children: Recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics
Lynne M. Mofenson,Michael T. Brady,Susie P Danner,Kenneth L. Dominguez,Rohan Hazra,Edward Handelsman,Peter L. Havens,Steve Nesheim,Jennifer S. Read,Leslie Serchuck,Russell B. Van Dyke +10 more
TL;DR: This report updates and combines into one document earlier versions of guidelines for preventing and treating opportunistic infections (OIs) among HIV-exposed and HIV-infected children, last published in 2002 and 2004.
References
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Infectious Diseases of the Fetus and Newborn Infant
TL;DR: Infectious diseases of the fetus and newborn infant, Infectious diseases in the fetus as mentioned in this paper, infection of the newborn infant and the mother, infection of a fetus and infection of an infant.
Journal ArticleDOI
Pneumocystis carinii Infection: Evidence for High Prevalence in Normal and Immunosuppressed Children
TL;DR: These studies indicate that subclinical P. carinii infection is highly prevalent in normal children, analogous to other opportunistic infections where active disease is manifest predominantly in the compromised host.
Journal Article
Pneumocystis carinii; etiologic agent of interstitial plasma cell pneumonia of premature and young infants.
TL;DR: It is essential that American pediatricians be aware of this parasite as a potential human pathogen and establish clearly what role this organism plays in the pathogenesis of human disease and settle the controversy as to whether it is fungal or protozoan.
Journal ArticleDOI
Parasitologic and Serologic Observations of Infection with Pneumocystis in Humans
TL;DR: The age-related data from the normal children suggested that nearly 100% of children are infected with Pneumocystis during the first two years of life.
Journal ArticleDOI
Efficacy of Trimethoprim and Sulfamethoxazole in the Prevention and Treatment of Pneumocystis carinii Pneumonitis
TL;DR: A combination of trimethoprim and sulfamethoxazole was effective in the prevention and treatment of Pneumocystis carinii pneumonitis in cortisonetreated rats, and rifampin and clindamycin, separately or in combination with pentamidine, were ineffective.
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Pneumocystis carinii Infection: Evidence for High Prevalence in Normal and Immunosuppressed Children
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