Journal ArticleDOI
Observations on the site of origin of serum γ-glutamyl-transpeptidase
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TLDR
It is suggested that the ratio of the rise in γ-glutamyltranspeptidase to the riseIn alkaline phosphatase is a useful indicator pointing to the site of a lesion in the hepatobiliary system.About:
This article is published in Clinica Chimica Acta.The article was published on 1969-11-01. It has received 74 citations till now. The article focuses on the topics: Alkaline phosphatase & Common bile duct.read more
Citations
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Book ChapterDOI
Gamma-glutamyl transpeptidase.
TL;DR: This chapter discusses the measurement of the serum γ-glutamyl transpeptidase (GGTP) in the clinical laboratory and its application to diagnosis.
Journal ArticleDOI
Rat liver canalicular membrane vesicles. Isolation and topological characterization.
TL;DR: Data indicate that the isolated canalicular membrane vesicles are exclusively oriented right-side-out and that gamma-glutamyltransferase and aminopeptidase M are located on the luminal side of rat liver canalicular plasma membranes.
Journal ArticleDOI
Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process.
TL;DR: This interorgan model of mercapturic acid synthesis is based largely on the interorgan distribution of the enzymes involved in their formation, and in particular of the enzyme gamma-glutamyltransferase, the only protein known to initiate the breakdown of glutathione S-conjugates.
Journal ArticleDOI
Is serum gamma-glutamyltransferase a misleading test?
R Penn,D J Worthington +1 more
TL;DR: It is rare to find a biochemical test that is both tissue specific and disease specific, and y-glutamyltransferase activity appears to be no exception, and the claimed advantage of its sensitivity is marred by its lack of specificity.
Journal ArticleDOI
The tissue activities of some diagnostic enzymes in ten mammalian species
R.B. Clampitt,R.J. Hart +1 more
TL;DR: The tissue distribution of the enzymes of intermediary metabolism must be known before they are used as diagnostic aids in a particular species, and how the plasma activities of these enzymes alter in that species after experimental lesions have been induced is needed.
References
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Book
Methods of Biochemical Analysis
TL;DR: The Radiation Inactivation Method as a Tool to Study Structure-Function Relationships in Proteins Immunoassay with Electrochemical Detection and Theory and Newer Technology Assays for Superoxide Dismutase are studied.
Journal ArticleDOI
Synthesis of peptides in enzymic reactions involving glutathione.
C. S. Hanes,F. J. R. Hird +1 more
Journal ArticleDOI
Histochemical Demonstration of Gamma-Glutamyl Transpeptidase
Journal ArticleDOI
A routine procedure for estimating serum γ-glutamyl-transpeptidase activity
TL;DR: A rapid sensitive micromethod is described, for the estimation of serum γ-glutamyltranspeptidase, which is readily adaptable to the performance of batch work.
Journal ArticleDOI
The colorimetric determination of γ-glutamyl transpeptidase with a synthetic substrate
Julius A. Goldbarg,Orrie M. Friedman,Esteban P. Pineda,Edgar E. Smith,Ramesh Chatterji,Edward H. Stein,Alexander M. Rutenburg +6 more
TL;DR: Evidence is presented that the kidney enzyme which accomplishes the liberation of aniline from this substrate is γ-glutamyl transpeptidase, and that enzymic activity was highest in the kidney in all species.