Journal ArticleDOI
Phosphate transport in rat-liver mitochondria.
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The kinetics of Pi transport are consistent with previous observations that there is a direct exchange betweenOH− and Pi, but not between OH− and malate, and the equilibrium distribution of H2PO4− and OH− deviates from the Donnan distribution.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1971-03-02. It has received 92 citations till now.read more
Citations
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Conservation and transformation of energy by bacterial membranes.
TL;DR: Energy Transductions in Mitochondria and the Role of the Membrane in Motility, Bacteriocins and the Energized State are studied.
Journal ArticleDOI
Insulin, ketone bodies, and mitochondrial energy transduction.
Keizo Sato,Yoshihiro Kashiwaya,C A Keon,N Tsuchiya,King,George K. Radda,Britton Chance,Kieran Clarke,Richard L. Veech +8 more
TL;DR: The moderate ketosis characteristic of prolonged fasting or type II diabetes appears to be an elegant compensation for the defects in mitochondrial energy transduction associated with acute insulin deficiency or mitochondrial senescence.
Journal ArticleDOI
Determination of the mitochondrial protonmotive force in isolated hepatocytes.
TL;DR: The intracellular distribution of lipophilic ions and weak acids and bases was studied in intact hepatocytes as indicators of gradients of pH and membrane potential and a total mitochondrial protonmotive force in the intact cell in excess of -200 mV was obtained.
Journal ArticleDOI
Phosphate transport in rat liver mitochondria. Kinetics and energy requirements.
TL;DR: Measurements of phosphate uptake, along with determinations of intramitochondrial volumes, show that the phosphate transport system catalyzes transport of phosphate against a concentration gradient at 0°, consistent with the hypothesis that concentrative uptake of phosphate can be driven by the pH gradient of the mitochondrial membrane.
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CALCULATION OF INTRACELLULAR pH FROM THE DISTRIBUTION OF 5,5-DIMETHYL-2,4-OXAZOLIDINEDIONE (DMO). APPLICATION TO SKELETAL MUSCLE OF THE DOG
TL;DR: There is a great deal of evidence that membranes of animal and plant cells in general are characterized by free permeability to the undissociated forms of weak organic acids and bases and by impermea.
Journal ArticleDOI
Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria.
P. Mitchell,J. Moyle +1 more
TL;DR: The effects of changing Δp in mitochondrial suspensions in State 4 with uncoupling agent and with pulses of acid, alkali, calcium salt and ADP have been found to be in accord with the chemiosmotic hypothesis.