Patent
Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
TLDR
In this article, a method for detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exogeneous cells, in an amount sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a protoporphyryrin IX in the exogenous cells, followed by exposure of the exogene cells to light of photoactivating wavelengths.Abstract:
Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or precursor thereof is administered to the patient, or contacted to the exogenous cells, in an amount sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a protoporphyrin IX in the exogenous cells, followed by exposure of the exogenous cells to light of photoactivating wavelengths.read more
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References
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Journal ArticleDOI
Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience.
TL;DR: In the ongoing clinical trial of ALA-induced Pp IX photodynamic therapy, the response rate for basal cell carcinomas following a single treatment has been 90% complete response and 7.5% partial response for the first 80 lesions treated.
Journal ArticleDOI
Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy.
TL;DR: Preclinical studies in experimental animals and human volunteers indicate that ALA can induce a localized tissue-specific photosensitization if administered by intradermal injection, opening the possibility of using ALA-induced PpIX to treat tumors that are too thick or that lie too deep to be accessible to either topical or locally injected ALA.
Journal ArticleDOI
Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid: An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?
Peter Wolf,E. Rieger,Helmut Kerl +2 more
TL;DR: Topical photodynamic therapy with endogenous porphyrins is effective for superficial epithelial skin tumors and only 1 of 10 nodulo-ulcerative basal cell carcinomas completely resolved.
Journal Article
Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence.
TL;DR: The skin of albino mice given 5-aminolevulinic acid by intraperitoneal injection rapidly developed the characteristic red fluorescence of protoporphyrin IX and appeared to recover completely except for a persistent reduction in the number of hair follicles.
Journal ArticleDOI
Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins
Zvi Malik,H Lugaci +1 more
TL;DR: Cells photosensitized after 5-6 days of culture were completely disintegrated leaving a nuclear remnant and an enormously swollen nuclear envelope, and the culture time dependence of the process showed an interrelationship between the photodynamic effect and porphyrin accumulation sites in cellular compartments.