Journal ArticleDOI
Photocyclization of .alpha.-(o-benzyloxyphenyl)acetophenone: triplet state .epsilon.-hydrogen abstraction
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This article is published in Journal of Organic Chemistry.The article was published on 1985-02-01. It has received 35 citations till now. The article focuses on the topics: Hydrogen atom abstraction & Triplet state.read more
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Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.
Satoshi Shuto,Shizuka Ono,Yukako Hase,Yoshihito Ueno,Tomohiro Noguchi,Kiyonori Yoshii,Akira Matsuda +6 more
TL;DR: Conformationally restricted analogs with different stereochemistries, namely 1-phenyl-2-(1-aminoalkyl)-N,N-diethylcyclopropanecarboxamindes (2, 3, ent-2, and ent-3), were designed and synthesized and were more efficient than milnacipran as NMDA receptor antagonists.
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Diastereospecific synthesis of diaziridines from D-mannitol. Access to chiral α-aminoacids.
TL;DR: In this paper, the nucleophilic opening of chiral diastereoisomeric diaziridines obtained from D- mannitol leads to precursors of D or L α-aminoacids (or aldehydes) and also provides a means of synthesizing polyhydroxylated piperidines.
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Kinetic resolution in the directed hydrogenation of N-substituted -(aminoalkyl) acrylates, precursors of optically active -amino acids.
TL;DR: In this article, the NHCOCH 3 and NHCO 2 Bu t substitutions were used to direct groups in homogeneous hydrogenation in a variety of allylic substituents.
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A Novel Approach to Chiral, Nonracemic Pyrrolidines by 5-exo-trig Diastereoselective Radical Cyclization on Acrylamides Derived from (−)-8-Aminomenthol
TL;DR: In this paper, unsaturated amides supported on perhydro-1,3-benzoxazines derived from (−)-8-aminomenthol as chiral auxiliaries undergo regio-and stereoselective 5-exo-trig radical cyclization leading to diastereomeric five-membered lactams.
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Synthesis of allyl selenides by palladium-catalyzed decarboxylative coupling
Shelli R. Waetzig,Jon A. Tunge +1 more
TL;DR: This communication details the Pd-catalyzed decarboxylation of selenocarbonates; use of a chiral nonracemic catalyst affords enantioenriched allyl selenides which undergo stereospecific [2,3]-sigmatropic rearrangements to form enantiaenriched allylic amines and chlorides.