Open AccessJournal Article
Photoreceptor layer features in eyes with closed macular holes: Optical coherence tomography findings and correlation with visual outcomes
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Morphology and thickness of the foveal photoreceptor layer correlate well with macular function after successful MHS, and Outer retinal features appear to be more important to determine postoperative visual function.Abstract:
Purpose: Study correlation between optical coherence tomography (OCT) findings and visual acuity (VA) outcomes after successful macular hole surgery (MHS).Design: Retrospective cross- sectional study. Methods: PostoperativeOCT scans were analyzed in 34 eyes of 30 patients. Raw files of horizontal and vertical OCT scans were exported to Adobe Photoshop 7.0. Measured parameters included central foveal thickness, photoreceptor thickness, photoreceptor reflectivity, and relative reflectivity of photoreceptor to retinal pigment epithelium in the foveal area. Foveal configuration was subjectively graded. Results: OCT scans were obtained at a median of 2 years (1 month to 10 years) postoperatively. The median visual acuity was 20/80 (20/50 to 8/200) preoperatively and 20/50 (20/20 to5/200) postoperatively. The median foveal thickness was 198.5 μ (148 to 283). The mean (SD) photoreceptor layer thickness was 16.5 (8) μ in the 500 μ area and 17.5 (8) μ in the 1000 μ area. Mean (SD) of relative reflectivity of the photoreceptor layer was 0.60 (0.10) in both 500 μ and 1000 μ area. Postoperative VA did not correlate with foveal thickness or foveal configuration. Central (500 μ and 1000 μ ) photoreceptor thicknesswas significantly correlated with final VA(r=.38, P=.026, each). Relative reflectivity of photoreceptors to retinal pigment epithelium in the 500 μ area was correlated with postoperative VA at a borderline significance (r=.32, P=.07). Relative reflectivity of photoreceptors to retinal pigment epithelium in the 1000 μ area was not significantly correlated with postoperative VA (r=.27, P=.12). Conclusion: Specific retinal features can be assessed from OCT images. Morphology and thickness of the foveal photoreceptor layer correlate well with macular function after successful MHS. Outer retinal features appear to be more important to determine postoperative visual function. Inner retinal features may be more relevant for the ophthalmoscopic appearance of anatomic closure.read more
Citations
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Journal ArticleDOI
Characterization of Outer Retinal Morphology with High-Speed, Ultrahigh-Resolution Optical Coherence Tomography
Vivek J. Srinivasan,B.K. Monson,Maciej Wojtkowski,Maciej Wojtkowski,Maciej Wojtkowski,Richard A. Bilonick,Iwona Gorczynska,Iwona Gorczynska,Royce W.S. Chen,Jay S. Duker,Joel S. Schuman,James G. Fujimoto +11 more
TL;DR: Quantitative maps of outer retinal layers showed clear differences between the cone-dominated fovea and the rod-dominated parafovea, indicating that photoreceptor morphology can explain the appearance of the outer retina in high-speed, UHR OCT images.
Journal ArticleDOI
Retinal assessment using optical coherence tomography
Rogério A. Costa,M. Skaf,Luiz Alberto S. Melo,Daniela Calucci,José A. Cardillo,J.C. Castro,David Huang,Maciej Wojtkowski +7 more
TL;DR: A brief look in the past of OCT is taken and the key basic physical principles of this imaging technology are explained and the future directions of this exceptional technique are commented on.
Journal ArticleDOI
Photoreceptor inner/outer segment defect imaging by spectral domain OCT and visual prognosis after macular hole surgery.
Jaeryung Oh,William E. Smiddy,Harry W. Flynn,Giovanni Gregori,Brandon J. Lujan,Brandon J. Lujan +5 more
TL;DR: BCVA after MHS correlates with objectively ascertainable SD-OCT measurements of IS/OS defects and other features, and the postoperative area of the IS/ OS defect correlates more strongly with BCVA than do linear-based measurements.
Journal ArticleDOI
Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging.
S. Alam,Robert J. Zawadzki,Stacey S. Choi,Christina Gerth,Susanna Soon Chun Park,Lawrence S Morse,John S. Werner +6 more
TL;DR: This technique provides additional information that can be missed on single OCT images and provides an accurate way to image large or complex lesions, and allows B-scan and C-scan reconstructions to be made that provide additional perspectives into retinal structures that may be missed using traditional imaging methods.
Journal ArticleDOI
Spectral-domain optical coherence tomography images of inner/outer segment junctions and macular hole surgery outcomes
Maiko Inoue,Yoichiro Watanabe,Akira Arakawa,Shimpei Sato,Satoshi Kobayashi,Kazuaki Kadonosono +5 more
TL;DR: The postoperative IS/OS junction may play an important role in visual recovery after macular hole surgery and SD-OCT is useful for quantitatively measuring IS/ OS junction defects.
References
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Journal ArticleDOI
Characterization of Outer Retinal Morphology with High-Speed, Ultrahigh-Resolution Optical Coherence Tomography
Vivek J. Srinivasan,B.K. Monson,Maciej Wojtkowski,Maciej Wojtkowski,Maciej Wojtkowski,Richard A. Bilonick,Iwona Gorczynska,Iwona Gorczynska,Royce W.S. Chen,Jay S. Duker,Joel S. Schuman,James G. Fujimoto +11 more
TL;DR: Quantitative maps of outer retinal layers showed clear differences between the cone-dominated fovea and the rod-dominated parafovea, indicating that photoreceptor morphology can explain the appearance of the outer retina in high-speed, UHR OCT images.
Journal ArticleDOI
Retinal assessment using optical coherence tomography
Rogério A. Costa,M. Skaf,Luiz Alberto S. Melo,Daniela Calucci,José A. Cardillo,J.C. Castro,David Huang,Maciej Wojtkowski +7 more
TL;DR: A brief look in the past of OCT is taken and the key basic physical principles of this imaging technology are explained and the future directions of this exceptional technique are commented on.
Journal ArticleDOI
Photoreceptor inner/outer segment defect imaging by spectral domain OCT and visual prognosis after macular hole surgery.
Jaeryung Oh,William E. Smiddy,Harry W. Flynn,Giovanni Gregori,Brandon J. Lujan,Brandon J. Lujan +5 more
TL;DR: BCVA after MHS correlates with objectively ascertainable SD-OCT measurements of IS/OS defects and other features, and the postoperative area of the IS/ OS defect correlates more strongly with BCVA than do linear-based measurements.
Journal ArticleDOI
Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging.
S. Alam,Robert J. Zawadzki,Stacey S. Choi,Christina Gerth,Susanna Soon Chun Park,Lawrence S Morse,John S. Werner +6 more
TL;DR: This technique provides additional information that can be missed on single OCT images and provides an accurate way to image large or complex lesions, and allows B-scan and C-scan reconstructions to be made that provide additional perspectives into retinal structures that may be missed using traditional imaging methods.
Journal ArticleDOI
Spectral-domain optical coherence tomography images of inner/outer segment junctions and macular hole surgery outcomes
Maiko Inoue,Yoichiro Watanabe,Akira Arakawa,Shimpei Sato,Satoshi Kobayashi,Kazuaki Kadonosono +5 more
TL;DR: The postoperative IS/OS junction may play an important role in visual recovery after macular hole surgery and SD-OCT is useful for quantitatively measuring IS/ OS junction defects.