Journal ArticleDOI
Physiological and pharmacological aspects of adrenergic receptor classification
Ariens Ej,A.M. Simonis +1 more
TLDR
The alpha 2- and beta 2-character of the presynaptic receptors matches that of the corresponding extrajunctional receptors, which indicates that a circulating catecholamine, namely epinephrine, is involved in the regulation of adrenergic transmitter release.About:
This article is published in Biochemical Pharmacology.The article was published on 1983-05-15. It has received 122 citations till now. The article focuses on the topics: Adrenergic receptor & Non-noradrenergic, non-cholinergic transmitter.read more
Citations
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Journal ArticleDOI
Autoradiographic visualization of beta-adrenoceptor subtypes in human lung.
TL;DR: Autoradiography revealed that beta-receptors were widely distributed, with dense labeling overAirway epithelium, alveolar walls, and submucosal glands, and a lower density of grains over airway and vascular smooth muscle.
Journal ArticleDOI
Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats.
Jean-Francois Pittet,Jeanine P. Wiener-Kronish,M. C. McElroy,Hans G. Folkesson,Michael A. Matthay +4 more
TL;DR: Evidence is provided for a previously unrecognized mechanism that can protect against or hasten the resolution of alveolar edema in pathological conditions, such as septic shock, that are associated with the endogenous release of catecholamines.
Journal ArticleDOI
Adrenergic Receptors — Evolving Concepts and Clinical Implications
TL;DR: Norepinephrine acts as a neurotransmitter at certain sites in the central nervous system and in the sympathetic nervous system at postganglionic neuroeffector junctions and can also act as a circulating hormone.
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Low-frequency Spectral Power of Heart Rate Variability Is Not a Specific Marker of Cardiac Sympathetic Modulation
TL;DR: Although preganglionic cardiac sympathetic blockade reduced the LF/HF ratio during tilt, it did not alter spectral power in the LF band during rest or tilt, and low‐frequency spectral power is unlikely to specifically reflect cardiac sympathetic modulation in humans.
Journal ArticleDOI
Plasma catecholamines—analytical challenges and physiological limitations
TL;DR: Plasma NA is a frequently used marker for sympathetic nerve activity in humans, but the data obtained are often misinterpreted due to lack of appreciation of the physiological determinants of the NA concentration measured.
References
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Journal ArticleDOI
Differentiation of receptor systems activated by sympathomimetic amines.
TL;DR: The classification of receptor systems which are activated by sympathomimetic amines has engaged the attention of many investigators as mentioned in this paper, who have suggested the convenient designations of alpha (α) and beta (β) to distinguish major differences in the responses elicited in various organ systems.
Journal ArticleDOI
Sixth gaddum memorial lecture national institute for medical research, mill hill, january 1977
TL;DR: The topic of the lecture will be the presence of presynaptic receptors in noradrenergic nerve endings and their role in the regulation of the release of the neurotransmitter upon arrival of nerve impulses.
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Differentiation of receptors responsive to isoproterenol.
TL;DR: Structural modification of 1-(3,4-dihydroxyphenyl)-2-amino-ethanol, by adding a methyl or ethyl group at the carbon alpha to the nitrogen or by adding various alkyl groups in the nitrogen center, changes sympathomimetic activity, indicating that the β-receptor population can be divided into two distinct groups.
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beta1- and beta2-Adrenergic receptors in rat cerebral cortex are independently regulated.
TL;DR: The results suggest that the beta-adrenergic receptors in rat cortex involved in neuronal function are primarily of the beta1 subtype.