Journal ArticleDOI
Placental free-fatty-acid transfer and fetal adipose-tissue development: an explanation of fetal adiposity in infants of diabetic mothers
AndrewJ. Szabo,Olga Szabo +1 more
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TLDR
The hypothesis is compatible with the paradoxical finding that, despite their normal (or near normal) blood-sugar levels, prediabetic women often give birth to obese " diabetic-type " babies, while overtly hyperglycaemic diabetic mothers may have normal or even small newborns.About:
This article is published in The Lancet.The article was published on 1974-08-31. It has received 83 citations till now. The article focuses on the topics: Adipose tissue & Triglyceride.read more
Citations
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Excessive Obesity in Offspring of Pima Indian Women with Diabetes during Pregnancy
TL;DR: The findings strongly suggest that the prenatal environment of the offspring of diabetic women results in the development of obesity in childhood and early adulthood.
Journal ArticleDOI
Role of the prenatal environment in the development of obesity.
TL;DR: Whether the maternal factors of diabetes, obesity, and pregnancy weight gain alter the intrauterine environment and thereby increase the risk of later obesity in the offspring is examined.
Journal ArticleDOI
Diabetic pregnancy and perinatal morbidity
John L. Kitzmiller,John P. Cloherty,M.Donna Younger,Ashraf Tabatabaii,Suzanne B. Rothchild,Ilene R. Sosenko,Michael F. Epstein,Shailini Singh,Raymond K. Neff +8 more
TL;DR: Pregnancy outcome was analyzed in 147 diabetic women, 71 per cent of whom were dependent on insulin for more than 10 years, and polyhydramnios was a frequent maternal complication and was associated with premature labor and neonatal death in two cases.
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Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic
TL;DR: The metabolic environment of obese diabetic women and lipid metabolism affecting fetal adiposity is examined and the importance of understanding these issues relates to the increasing trends of obesity worldwide with perinatal programming of metabolic dysfunction in the offspring.
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Developmental Trajectories of Overweight During Childhood: Role of Early Life Factors
TL;DR: The goal was to identify developmental trajectories of overweight in children and to assess early life influences on these trajectories.
References
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Journal ArticleDOI
The outcome of diabetic pregnancies in relation to the mother's blood sugar level.
TL;DR: The increased survival rate was parallelled by a decreased morbidity in the infants, and the perinatal mortality rate sank from 23.6 per cent in the group with a mean blood sugar level above 150 mg per 100 ml.
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Neonatal deaths among infants of diabetic mothers. Postmortem findings in ninety-five infants.
TL;DR: The newborn infant of the diabetic mother shows anatomical and biochemical peculiarities which may be indicative of the mechanisms of fetal wastage operative under these conditions, and detailed postmortem findings in a uniquely large series of these infants are reported.
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Body composition of infants of diabetic mothers by direct analysis.
B. A. Fee,William B. Weil +1 more
TL;DR: The investigations to be reported here were begun in 1959 in an attempt to describe the precise relationships between body water, extraand intracellular fluid, cellular solids, skeletal solids and body fat, and suggest that the somatic changes are independent of the disturbed pathologic physiology manifest in the neonatal period.