[Platelet-rich plasma for treating acute wounds: a meta-analysis].
Li Wang,Zhen-Yang Gu,Chun-Ji Gao +2 more
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TLDR
Use of PRP can shorten acute wound healing time and length of hospital stay, reduce the incidence of disturbed wound healing and blood products transfusion and alleviate post-traumatic pain, and it has some effect on the control of wound infections.Abstract:
Objective
To evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of acute wounds.
Methods
Randomized controlled trials (RCT) were identified from PubMed (1950.1-2014.2), Cochrane Central Register of Controlled Trials (CENTRAL, issue 4, 2014) of Cochrane Library, China National Knowledge Infrastructure (CNKI, 1979.1-2014.2), China Biology Medicine (CBM, 1978.1-2014.2) WANFANG database (1990.1-2014.2). References of retrieved articles were also identified. The quality of each RCT was evaluated by the Cochrane collaboration's tool for assessing the risk of bias. Data analysis was performed with Review Manager 5.1 to evaluate the efficacy of PRP in the treatment of acute wounds.
Results
A total of 13 articles involving 982 patients were included. The results of systematic review and analysis showed that wound healing time of PRP treatment group was shorter than that of control group, so did length of hospital stay (mean difference (MD): -1.45, 95%CI: -2.07 to -0.83; P<0.01), the incidence of wound healing disturbance in PRP treatment group was less than that of control group (relative risk (RR): 0.11, 95%CI: 0.01 to 0.83; P<0.05), so did blood product transfusion. Moreover, post-traumatic pain level of PRP treatment group was lower than that of control group (MD: -1.26, 95%CI: -1.71 to -0.82; P<0.01).
Conclusion
Use of PRP can shorten acute wound healing time and length of hospital stay, reduce the incidence of disturbed wound healing and blood products transfusion and alleviate post-traumatic pain. Moreover, it has some effect on the control of wound infections.
Key words:
Platelet-rich plasma; Wounds and injuries; Wound healing; Meta-analysis; Systematic reviewread more
Citations
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Journal ArticleDOI
Use of platelet-rich plasma to facilitate wound healing.
TL;DR: The concentration of IL‐1β and TNFα in wound fluid on day 1 and day 5 after operation was higher for the treatment group as opposed to the control group, which was linked to the influence of PRP on inflammatory and granulation phases of the healing process.
Journal ArticleDOI
Combined Use of Autologous Stromal Vascular Fraction Cells and Platelet-Rich Plasma for Chronic Ulceration of the Diabetic Lower Limb Improves Wound Healing.
TL;DR: Evaluating the clinical efficacy of a new method that applied stromal vascular fraction cells and platelet-rich plasma together in the treatment of recalcitrant chronic diabetic ulcer of lower limb revealed that the new treatment is efficient to achieve wound healing in patients with recalcitrance.
Journal ArticleDOI
Platelet-Rich Plasma in the Treatment of Subcutaneous Venous Access Device Scars: A Head-to-Head Patient Survey
TL;DR: Platelet-rich plasma products such as Arthrex ACP are safe to use and present an additional option in improving surgical outcome and may be improved to 10% dissatisfaction when a PRP product is used.
Journal ArticleDOI
Platelet-Rich Plasma (PRP) in Breast Cancer Patients: An Application Analysis of 163 Sentinel Lymph Node Biopsies.
Christian Eichler,C. Baucks,J. Üner,Caroline Pahmeyer,Dominik Ratiu,Berthold Gruettner,Wolfram Malter,M Warm +7 more
TL;DR: Complication rates and oncological follow-up showed PRP to be applicable to use in a sentinel node biopsy scenario in breast cancer patients, but PRP does not seem to increase rates of local recurrence within this 30-month follow- up time frame.
Journal ArticleDOI
Developing Ideal Solution for Acute Wound Treatment by Regenerative Medicine
TL;DR: This method of treatment assisted with Platelet rich plasma as regenerative medicine product is safe, easy, effective and efficient mode of wound management, which can be adopted universally as an ideal treatment for wounds, minimising the morbidity and preserving the resources across the globe.