Journal ArticleDOI
Platelet-Rich Plasma Injections in the Treatment of Chronic Rotator Cuff Tendinopathy A Randomized Controlled Trial With 1-Year Follow-up
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TLDR
At 1-year follow-up, a PRP injection was found to be no more effective in improving quality of life, pain, disability, and shoulder range of motion than placebo in patients with chronic RCT who were treated with an exercise program.Abstract:
Background:Rotator cuff tendinopathy (RCT) is a significant source of disability and loss of work. Platelet-rich plasma (PRP) has been suggested to be beneficial in the treatment of RCT.Purpose:To investigate the effect of PRP injections on pain and shoulder functions in patients with chronic RCT.Study Design:Randomized controlled trial; Level of evidence, 1.Methods:A total of 40 patients, 18 to 70 years of age, with (1) a history of shoulder pain for >3 months during overhead-throwing activities, (2) MRI findings of RCT or partial tendon ruptures, and (3) a minimum 50% reduction in shoulder pain with subacromial injections of an anesthetic were included in this placebo-controlled, double-blind randomized clinical trial. Patients were randomized into a PRP group (n = 20) or placebo group (n = 20). Patients received an ultrasound-guided injection into the subacromial space that contained either 5 mL of PRP prepared from autologous venous blood or 5 mL of saline solution. All patients underwent a 6-week sta...read more
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Journal ArticleDOI
Neovascularization in Meniscus and Tendon Pathology as a Potential Mechanism in Regenerative Therapies: Special Reference to Platelet-Rich Plasma Treatment
TL;DR: The stabilization of the neovessels required to achieve the healed tissue, together with the standardization of the PRP injections, can offer an alternative future therapeutic approach for the treatment of tendinopathy and meniscal injuries.
Journal ArticleDOI
Influence of Acromial Morphologic Characteristics and Acromioclavicular Arthrosis on the Effect of Platelet-Rich Plasma on Partial Tears of the Supraspinatus Tendon
Juan de Dios Berná-Mestre,Carmen Muñoz Fernández,Guillermo Carbonell,Ana Isabel Ballesteros García,José A García-Vidal,Francesc Medina i Mirapeix,Juan D. Berná-Serna +6 more
TL;DR: Ultrasound-guided PRP infiltration of partial tears of the SST relieves pain and improves shoulder mobility, but its effect on the size of the tear is influenced by the morphologic characteristics of the acromion and the presence of AC arthrosis.
Journal ArticleDOI
Bibliometric analysis of the top 50 highly cited articles on platelet-rich plasma in osteoarthritis and tendinopathy.
TL;DR: The top 50 most cited articles on the use of platelet-rich plasma (PRP) and the most cited and influential publications regarding PRP are defined to further research in this area.
Journal ArticleDOI
Full-Thickness Rotator Cuff Tears in the Throwing Athlete
TL;DR: Throwing athletes offer a unique challenge as the line between adaptive and pathologic is often blurred and the presence of an abnormality on imaging may not directly indicate the reason for discomfort, but as a thrower progresses through their career, there is a higher incidence of abnormalities on advanced imaging, including rotator cuff tears.
Journal ArticleDOI
Platelet-rich plasma for tendinopathy and osteoarthritis: a narrative review
TL;DR: This review aims to do a comprehensive review of the scientific evidence for the efficiency of PRP application in tendinopathy and osteoarthritis, and reports some benefits in regard to pain and functionality, but further investigations are needed.
References
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Journal ArticleDOI
Platelet-rich plasma (PRP): what is PRP and what is not PRP?
TL;DR: The definition of PRP, its safety, its proper development, and its most efficacious means of application are discussed.
Journal ArticleDOI
Development of a shoulder pain and disability index.
TL;DR: High negative correlations between changes in SPADi scores and changes in shoulder ROM indicated the SPADI detected changes in clinical status over short time intervals, and should prove useful for both clinical and research purposes.
Journal ArticleDOI
Treatment of Chronic Elbow Tendinosis With Buffered Platelet-Rich Plasma
Allan Mishra,Terri Pavelko +1 more
TL;DR: Treatment of patients with chronic elbow tendinosis with buffered platelet-rich plasma reduced pain significantly in this pilot investigation and should be considered before surgical intervention.
Journal ArticleDOI
Shoulder disorders in general practice: incidence, patient characteristics, and management.
TL;DR: Although the patient characteristics of specific disorders showed some similarities with the clinical pictures described in the literature, further research is required to demonstrate whether the proposed syndromes indeed constitute separate disorders with a different underlying pathology, requiring different treatment strategies.
Journal ArticleDOI
Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial.
Robert J. de Vos,Adam Weir,Hans T. M. van Schie,Sita M A Bierma-Zeinstra,Jan A N Verhaar,Harrie Weinans,Johannes L. Tol +6 more
TL;DR: Among patients with chronic Achilles tendinopathy who were treated with eccentric exercises, a PRP injection compared with a saline injection did not result in greater improvement in pain and activity, and was not significantly different between both groups.