Journal ArticleDOI
Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA
TLDR
The kinetics and mechanism of binding of the anticancer drug cis-diamminedichloroplatinum(II), or cis-DDP, and its inactive trans isomer to chicken erythrocyte DNA at 37 o C have been investigated by 195 Pt NMR spectroscopy.Abstract:
The kinetics and mechanism of binding of the anticancer drug cis-diamminedichloroplatinum(II), or cis-DDP, and its inactive trans isomer to chicken erythrocyte DNA at 37 o C have been investigated by 195 Pt NMR spectroscopy. Both cis-and trans-DDP bind to DNA by two successive pseudo-first-order processes, forming monofunctional adducts ( 195 Pt NMR shifts near -2300 ppm) that subsequently close to bifunctional lesions (chemical shifts near -2450 ppm)read more
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Structure, Recognition, and Processing of Cisplatin-DNA Adducts.
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Formation and repair of interstrand cross-links in DNA
TL;DR: Bifunctional alkylating agents, platinum compounds, and psoralen can produce covalent adducts with DNA bases on both strands of DNA, leading ultimately to the formation of interstrand cross-links, which can act as absolute blocks to DNA replication and/or DNA transcription.