T
Timothy C. Johnstone
Researcher at University of California, Santa Cruz
Publications - 80
Citations - 6024
Timothy C. Johnstone is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 31, co-authored 70 publications receiving 4938 citations. Previous affiliations of Timothy C. Johnstone include Massachusetts Institute of Technology & University of Toronto.
Papers
More filters
Journal ArticleDOI
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
TL;DR: Recently, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs as mentioned in this paper.
Journal ArticleDOI
Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery
Yao-Rong Zheng,Kogularamanan Suntharalingam,Timothy C. Johnstone,Hyunsuk Yoo,Wei Lin,Jamar G. Brooks,Stephen J. Lippard +6 more
TL;DR: A series of platinum(IV) prodrugs designed specifically to enhance interaction with human serum albumin (HSA) for drug delivery was presented in this article. But, their performance was limited by the fact that the axial ligands of the prodrug were asymmetrically functionalized so as to mimic the overall features of a fatty acid.
Journal ArticleDOI
Beyond iron: non-classical biological functions of bacterial siderophores
TL;DR: An exposition of past and current work into non-classical functions of siderophores is presented and the directions in which this research is headed are highlighted.
Journal Article
Understanding and Improving Platinum Anticancer Drugs – Phenanthriplatin
TL;DR: Pricker et al. as discussed by the authors reviewed some of the recent work on phenanthriplatin, a cisplatin derivative in which a chloride ion is replaced by phenanthridine, and one of its analogues, the previously reported pyriaplatin.
Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery
Yao-Rong Zheng,Kogularamanan Suntharalingam,Timothy C. Johnstone,Hyunsuk Yoo,Wei Lin,Jamar G. Brooks,Stephen J. Lippard +6 more
TL;DR: A series of platinum(IV) prodrugs designed specifically to enhance interaction with human serum albumin (HSA) for drug delivery are presented, and it is suggested that the prodrug is buried below the surface of the protein.