Journal ArticleDOI
Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues☆
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This article is published in Microvascular Research.The article was published on 1984-09-01. It has received 27 citations till now.read more
Citations
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Journal Article
Transport of Molecules in the Tumor Interstitium: A Review
TL;DR: High interstitial pressure and low microvascular pressure may retard extravasation of molecules and cells in the tumor interstitium, especially in large tumors.
Journal ArticleDOI
Microvascular permeability of normal and neoplastic tissues.
TL;DR: These results on increased permeability and increased diffusivity in tumors provide a rational basis for the use of large-molecular-weight agents in the detection and treatment of solid tumors.
Journal ArticleDOI
A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
TL;DR: A simple, mechanistic model is developed that can be used to understand and predict the complex interplay between molecular size, affinity, and tumor uptake and is shown to be consistent with experimental observations from published targeting studies.
Journal ArticleDOI
Extravascular transport in normal and tumor tissues
TL;DR: Various types of experimental tumor models which have been used in animals to represent human tumors are discussed and mathematical models of extravascular transport are discussed from the prespective of two approaches: compartmental and distributed.
Journal ArticleDOI
Determinants of capillary permeability: a review of mechanisms based on single capillary studies in the frog.
TL;DR: Two complementary hypotheses are examined that describe the role of the intercellular junction in the regulation of capillary permeability and are based on experimental data obtained on individually perfused capillaries in frog mesentery and frog muscle.
References
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Journal ArticleDOI
Method for the determination of hexosamines in tissues.
TL;DR: During the course of investigations on the metabolism of hexosamines in animal tissues, absorption spectra of the color produced in the hexosamine method of Elson and Morgan revealed the presence of interfering chromogens.
Journal ArticleDOI
On the transport of compact particles through solutions of chain-polymers
TL;DR: In this article, the problem of providing a theoretical explanation for the empirical equation of Laurent, Bjork, Pietruszkiewicz & Persson (1963) which relates the relative retardation of the sedimentation of compact particles in solutions of hyaluronic acid to the radius of the particle and the concentration of hyaline acid was discussed.
Journal Article
Extravascular Diffusion in Normal and Neoplastic Tissues
TL;DR: Macromolecular transport in tumor tissue was hindered to a lesser extent than in normal tissue, which is consistent with reports of reduced contents of glycosaminoglycans, and markedly large interstitial space in tumors.
Journal ArticleDOI
Drag coefficients for the movement of rigid spheres through liquid-filled cylindrical pores
P.L. Paine,P. Scherr +1 more
TL;DR: Equivalent pore analysis has been used to describe lipid-insoluble solute permeation of capillary endothelial walls, red blood cell and axonal plasma membranes, and the nuclear envelope of eukaryotic cells in terms of movement through water-filled pores.
Journal ArticleDOI
Interstitial diffusion of macromolecules in the rat mesentery.
James R. Fox,Harold Wayland +1 more
TL;DR: In this paper, the authors measured the apparent diffusion coefficients of fluorescein isothiocyanate (FITC)-labeled dextrans (M w 3400-41,200) and rat serum albumin (RSA-fITC) in the interstitial space of the rat mesentery.
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