Journal ArticleDOI
Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide.
Istvan Szelenyi,Kay Brune +1 more
TLDR
The present results suggest the additional role of sulfhydryl-containing compounds localized in the gastric mucosa in the cytoprotection induced by a mild irritant or by aluminium hydroxide and aluminium hydoxidecontaining antacids as well.Abstract:
The involvement of sulfhydryl-containing compounds was investigated in the cytoprotective effect of certain antacids against ethanol-induced gastric mucosal damage in the rat. Not only the protective effect of a sulfhydryl containing compound,N-acetylcysteine, was abolished after pretreatment withN-ethylmaleimid, but also the adaptive cytoprotection induced by 20% ethanol. Pretreatment of the animals with the cyclooxygenase inhibitor indomethacin or with the thiol reagentN-ethylmaleimide significantly diminished the cytoprotection evoked by aluminum hydroxide. However, the protective effect of aluminium hydroxide could only be totally abolished by pretreatment with the combination of indomethacin andN-ethylmaleimide. The present results suggest the additional role of sulfhydryl-containing compounds localized in the gastric mucosa in the cytoprotection induced by a mild irritant or by aluminium hydroxide and aluminium hydroxidecontaining antacids as well.read more
Citations
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Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage
TL;DR: Current knowledge about the normal function of the gastric mucosal barrier; the role of prostaglandins in cytoprotection and repair; the mechanisms by which aspirin and other weak organic acids are absorbed by the stomach; and the subsequent cascade of events--including ion trapping and back diffusion of hydrogen ions--that leads to gastric erosion and bleeding are examined.
Journal ArticleDOI
Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats.
Istvan Szelenyi,Kay Brune +1 more
TL;DR: The present results suggest that superoxide free radicals are involved in the development of ethanol-induced gastric mucosal lesions, probably via an interaction with cellular membranes.
Journal ArticleDOI
Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats
TL;DR: It is suggested that CPSN play an important role in the gastroprotection by momordin Ic on ethanol-induced gastric mucosal lesions, and endogenous PGs, NO, and SHs interactively participate, in rats.
Journal ArticleDOI
Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing.
Yasuhiro Tsukimi,Susumu Okabe +1 more
TL;DR: It was concluded that HSPs might contribute to mucosal defense mechanisms and ulcer healing, most probably through protecting key enzymes related to cytoprotection.
References
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Journal ArticleDOI
Cytoprotection by Prostaglandins in Rats Prevention of Gastric Necrosis Produced by Alcohol, HCl, NaOH, Hypertonic NaCl, and Thermal Injury
TL;DR: In this paper, the authors show that prostaglandins, by a mechanism other than the inhibition of gastric acid secretion, maintain the cellular integrity of the gastric mucosa, and might be beneficial in the treatment of a variety of diseases in which gastric injury is present.
Book
Manual of Pharmacologic Calculations: With Computer Programs
TL;DR: A manual of Pharmacologic Calculations with Computer Programs with Computer programs, published in 1981, provides an introduction to the science of pharmacologic calculation and its applications in medicine.
Journal ArticleDOI
Cytoprotection by prostaglandins.
TL;DR: A new property of PG was discovered, called "cytoprotection,"!' which designates the prop- erty of many PG to protect the mucosa of the stom- ach and the intestine from becoming inflamed and necrotic, when this mucosa is exposed to noxious agents.
Journal ArticleDOI
Early Vascular Injury and Increased Vascular Permeability in Gastric Mucosal Injury Caused by Ethanol in the Rat
TL;DR: It is suggested that vascular injury is an early pathogenetic factor in the development of ethanol-induced gastric hemorrhagic erosions and the degree of vascular damage, unlike the injury to surface epithelial cells, is reduced by pretreatment with prostaglandin F2 beta or the sulfhydryl cysteamine.