Journal ArticleDOI
Prepregnancy obesity: A complex risk factor for selected birth defects
Reads0
Chats0
TLDR
Existing literature on the association between maternal obesity and birth defects is reviewed, potential underlying mechanisms are discussed, and research needed is suggested to improve understanding of this important association.Abstract:
Obesity is associated with increased risk of many adverse health conditions. During pregnancy, obesity presents particularly important challenges for both mother and baby. Over the last 20 years, studies have emerged indicating an association between prepregnancy weight and risks of birth defects. However, few studies have examined the mechanisms through which this association occurs. Understanding the underlying mechanisms may provide clues to public health strategies for the prevention of birth defects associated with maternal obesity. This article briefly reviews existing literature on the association between maternal obesity and birth defects, discusses potential underlying mechanisms, and suggests research needed to improve our understanding of this important association.read more
Citations
More filters
Journal ArticleDOI
Position of the Academy of Nutrition and Dietetics: Obesity, Reproduction, and Pregnancy Outcomes
Jamie Stang,Laurel G. Huffman +1 more
TL;DR: Analysis of the evidence suggests that there is good evidence to support the role of diet, physical activity, and behavior changes in promoting optimal weight gain during pregnancy; however, there is currently a relative lack of evidence in other areas related to reproductive outcomes.
Dissertation
Recreational drug use : a major risk factor for gastroschisis?
TL;DR: In this article, the authors tested the hypothesis that the birth prevalence of gastroschisis is positively associated with use of recreational drugs in early pregnancy, and they used a matched case-control study in three regions of the United Kingdom over the period January 2001 through August 2003.
Journal ArticleDOI
Clinical interventions for women with schizophrenia: pregnancy.
TL;DR: A comprehensive treatment program for schizophrenia needs to include services to women of childbearing age that address contraception, pregnancy, and postpartum issues, as well as safe and effective parenting, according to recent qualitative and quantitative literature.
Journal ArticleDOI
High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice
Malgorzata E. Skaznik-Wikiel,Delaney C. Swindle,Amanda A. Allshouse,Alex J. Polotsky,James L. McManaman +4 more
TL;DR: It is described for the first time that exposure to HFD causes significant reduction in primordial follicles, compromised fertility, produced higher proinflammatory cytokine levels, and increased ovarian macrophage infiltration, independent of obesity.
Journal ArticleDOI
Long-term consequences of obesity on female fertility and the health of the offspring.
TL;DR: The purpose of this review is to outline proposed models responsible for the short-term and long-term consequences of obesity on fertility and offspring development, and identify knowledge gaps where additional research is needed.
References
More filters
Journal ArticleDOI
Prevalence and trends in obesity among US adults, 1999-2008.
TL;DR: The increases in the prevalence of obesity previously observed do not appear to be continuing at the same rate over the past 10 years, particularly for women and possibly for men.
Journal ArticleDOI
Prevention of neural tube defects: Results of the Medical Research Council vitamin study
TL;DR: An unexplained elevated level of maternal serum alpha-fetoprotein in the second trimester of pregnancy is associated with an increased risk of subsequent fetal death, up to four to five months after alphafetoprotein screening.
Journal ArticleDOI
Disparities in rates of unintended pregnancy in the United States, 1994 and 2001.
TL;DR: The rate of unintended pregnancy in 2001 was substantially above average among women aged 18-24, unmarried (particularly cohabiting) women, low-income women, women who had not completed high school and minority women, but increased among poor and less educated women.
Journal ArticleDOI
Dietary Fiber, Glycemic Load, and Risk of Non—insulin-dependent Diabetes Mellitus in Women
Jorge Salmerón,JoAnn E. Manson,Meir J. Stampfer,Graham A. Colditz,Alvin L. Wing,Walter C. Willett +5 more
TL;DR: The hypothesis that diets with a high glycemic load and a low cereal fiber content increase risk of diabetes in women is supported and grains should be consumed in a minimally refined form to reduce the incidence of diabetes.
Journal ArticleDOI
Prevention of Neural-Tube Defects with Folic Acid in China
Robert J. Berry,Zhu Li,J D Erickson,Song Li,Cynthia A. Moore,Hong Wang,Joseph Mulinare,Ping Zhao,Lee-Yang C. Wong,Jacqueline Gindler,Shi-xin Hong,Adolfo Correa +11 more
TL;DR: Evaluated the outcomes of pregnancy in women who were asked to take a pill containing 400 μg of folic acid alone daily from the time of their premarital examination until the end of their first trimester of pregnancy, and identified 102 and 173 women with neural-tube defects.