Prevalence and Clinicoepidemiological Features of Moyamoya Disease in Japan. Findings From a Nationwide Epidemiological Survey
Shinichi Kuriyama,Yasuko Kusaka,Miki Fujimura,Kenji Wakai,Akiko Tamakoshi,Shuji Hashimoto,Ichiro Tsuji,Yutaka Inaba,Takashi Yoshimoto +8 more
TLDR
The estimated prevalence of moyamoya disease in Japan has almost doubled during the recent decade and the clinicoepidemiological features of the patients in the present study were almost similar to those obtained in previous ones.Abstract:
Background and Purpose— The objectives of the present study were to estimate an annual number of patients with moyamoya disease in Japan and to describe the clinicoepidemiological features of the disease. Methods— The study consisted of 2 questionnaire surveys, which were distributed to randomly selected departments of neurosurgery, internal medicine, neurology, cerebrovascular medicine, and pediatrics in hospitals throughout Japan. The first survey inquired about the number of the patients treated in 2003, and the second requested additional detailed clinicoepidemiological information about each patient identified in the first survey. Results— In 2003, the total number of patients treated in Japan was estimated at 7700 (95% confidence interval, 6300 to 9300). Sex ratio (women to men) of the patients was 1.8. For men, the peak of moyamoya disease was observed in patients aged 10 to 14 years and for women aged 20 to 24 years. Annual rate of newly diagnosed cases in 2003 was 0.54 per 100 000 population. Fam...read more
Citations
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Journal ArticleDOI
A genome-wide association study identifies RNF213 as the first Moyamoya disease gene
Fumiaki Kamada,Yoko Aoki,Ayumi Narisawa,Yu Abe,Shoko Komatsuzaki,Atsuo Kikuchi,Junko Kanno,Tetsuya Niihori,Masao Ono,Naoto Ishii,Yuji Owada,Miki Fujimura,Yoichi Mashimo,Yoichi Suzuki,Akira Hata,Shigeru Tsuchiya,Teiji Tominaga,Yoichi Matsubara,Shigeo Kure +18 more
TL;DR: Results indicate that RNF213 is the first identified susceptibility gene for MMD, and it is confirmed that mature lymphocytes express higher levels of Rnf213 mRNA than their immature counterparts.
Book ChapterDOI
Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis)
TL;DR: Moyamoya disease is a chronic progressive stenosis of the terminal portion of the bilateral internal carotid arteries which leads to the formation of an abnormal vascular network composed of collateral pathways at the base of the brain.
Journal ArticleDOI
Clinical outcome after 450 revascularization procedures for moyamoya disease. Clinical article.
Raphael Guzman,Marco Lee,Achal S. Achrol,Teresa Bell-Stephens,Michael Kelly,Huy M. Do,Michael P. Marks,Gary K. Steinberg +7 more
TL;DR: Revascularization surgery in patients with MMD carries a low risk, is effective at preventing future ischemic events, and improves quality of life, and patients in whom symptomatic MMD is diagnosed should be offered revascularized surgery.
Journal ArticleDOI
Moyamoya Disease: Epidemiology, Clinical Features, and Diagnosis
TL;DR: Different age peaks and different clinical presentations in each age group are also observed in MMD patients in the USA, andCatheter angiography is the diagnostic method of choice.
References
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Moyamoya disease--a review.
TL;DR: Treatment with perivascular sympathectomy and superior cervical ganglionectomy may be useful but more investigation needs to be carried out into the pathogenesis of the disease before more definitive therapy is realized.
Journal Article
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Guidelines for the diagnosis and treatment of spontaneous occlusion of the circle of Willis ("Moyamoya" disease)
Journal ArticleDOI
Epidemiological features of Moyamoya disease in Japan: findings from a nationwide survey
Kenji Wakai,Akiko Tamakoshi,Kiyonobu Ikezaki,Masashi Fukui,Takashi Kawamura,Rie Aoki,Masayo Kojima,Yingsong Lin,Yoshiyuki Ohno +8 more
TL;DR: A nationwide epidemiological survey was conducted in 1995 to estimate an annual number of patients treated for Moyamoya disease in Japan and to describe the clinico-epidemiological features, and the present findings were quite comparable with those obtained in the previous nationwide Epidemiological survey in 1990.
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