Propofol decreases cerebral blood flow velocity in anesthetized children.
TLDR
This study shows that a higher rate of prop ofol infusion is associated with lower CBFV and MAP values in children, and propofol’s cerebral vasoconstrictive properties may be responsible for this finding.Abstract:
Purpose
Propofol, by virtue of its favourable pharmacokinetic profile, is suitable for maintenance of anesthesia by continuous infusion during neurosurgical procedures in adults. It is gaining popularity for use in pediatric patients. To determine the effects of propofol on cerebral blood flow in children, middle cerebral artery blood flow velocity (Vmca) was measured at different levels of propofol administration by transcranial Doppler (TCD) sonography.read more
Citations
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Propofol: a review of its role in pediatric anesthesia and sedation
TL;DR: There is no direct evidence in humans for propofol-induced neurotoxicity to the infant brain; however, current concerns of neuroapoptosis in developing brains induced by prop ofol persist and continue to be a focus of research.
Journal ArticleDOI
Young age as a risk factor for impaired cerebral autoregulation after moderate to severe pediatric traumatic brain injury.
TL;DR: Age less than 4 yr was a risk factor for impaired cerebral autoregulation, independent of TBI severity, and age-related factors may play a role in the mechanisms maintaining or worsening cerebral autOREgulation in children after TBI.
Journal ArticleDOI
Total intravenous anesthesia: advantages for intracranial surgery.
TL;DR: TIVA with propofol is similar to inhaled anesthetics with regard to hemodynamic stability, emergence times, extubation times, early cognitive function, and adverse events.
Journal ArticleDOI
Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice
TL;DR: The advantages of total intravenous anesthesia (TIVA) have emerged and driven change in practice as mentioned in this paper, and these advantages will justify why TIVA will supercede inhalational anesthesia in future pediatric anesthetic practice.
Journal ArticleDOI
Impact of sevoflurane anesthesia on brain oxygenation in children younger than 2 years.
O. Rhondali,Simon Juhel,Sylvain Mathews,Quentin Cellier,François-Pierrick Desgranges,Aurélie Mahr,Mathilde De Queiroz,Agnès Pouyau,Khalid Rhzioual-Berrada,Dominique Chassard +9 more
TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on brain oxygenation in children younger than 2 years, a large number of patients were referred to the neonatal intensive care unit.
References
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Journal ArticleDOI
Pharmacokinetic model driven infusion of propofol in children
TL;DR: A computer controlled infusion device for propofol was used to induce and maintain general anaesthesia in 20 children undergoing minor surgical procedures and it was found that the values obtained were systematically overpredicted by the delivery system algorithm.
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Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study.
TL;DR: Validates the technique by comparing it to cerebral blood flow measured using intravenous Xenon133 and extracranial clearance recording and finds changes in MCA velocity reliably correlate with changes in cerebralBlood flow but the absolute velocity cannot be used as an indicator of CBF.
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Direct Cerebral Vasodilatory Effects of Sevoflurane and Isoflurane
TL;DR: In common with other volatile anesthetic agents, sevoflurane has an intrinsic dose-dependent cerebral vasodilatory effect, however, this effect is less than that of isofl Lurane.
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The Pharmacokinetics of Propofol in Children Using Three Different Data Analysis Approaches
Bideshwar K. Kataria,Sudha Ved,Honorato F. Nicodemus,Gregory R. Hoy,Dawn Lea,Michel Y. Dubois,Jaap W. Mandema,Steven L. Shafer +7 more
TL;DR: The pharmacokinetics of propofol in children are well described by a standard three-compartment pharmacokinetic model and weight was a significant covariate, and the weight-proportional model was supported by all three regression approaches.
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Induction and maintenance of propofol anaesthesia. A manual infusion scheme
TL;DR: The quality of induction and maintenance of anaesthesia was satisfactory in every patient and the decrease of systolic and diastolic arterial pressures at induction was much less than that previously described after larger induction doses of propofol.