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Psychotropic drug prescription for nursing home residents with dementia: prevalence and associations with non-resident-related factors.

TLDR
Prescription rates for antipsychotics are similar compared to other countries, and relatively low for antidepressants, anxiolytics, and hypnotics, which indicates that improvement of prescribing could provisionally best be targeted at resident-related factors.
Abstract
Objectives: To determine psychotropic drug prescription rates in nursing home residents with dementia and to identify associations with the so far understudied psychosocial non-resident-related factors.Method: A cross-sectional, observational, exploratory design as part of PROPER I (PRescription Optimization of Psychotropic drugs in Elderly nuRsing home patients with dementia). Participants were 559 nursing home residents with dementia, 25 physicians, and 112 nurses in the Netherlands. Psychotropic drug prescription, non-resident-related and known resident-related variables were measured to operationalize the themes of our previous qualitative analysis.Results: Fifty-six percent of residents were prescribed any psychotropic drug, 25% antipsychotics, 29% antidepressants, 15% anxiolytics, and 13% hypnotics, with large differences between the units. Multivariate multilevel regression analyses revealed that antipsychotic prescription was less likely with higher physicians’ availability (odds ratio 0.9...

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Does Organisational Culture Influence Prescribing in Care Homes for Older People?: A New Direction for Research.

TL;DR: Consideration of organisational culture within care-home settings may help to understand what drives prescribing decisions in this particularly vulnerable patient group and thus provide new directions for future strategies to promote quality care.
Journal ArticleDOI

Trends in Antipsychotic and Mood Stabilizer Prescribing in Long-Term Care in the U.S.: 2011-2014.

TL;DR: The likelihood of antipsychotic and mood stabilizer treatment did not decline for residents with depression or bipolar disorder, for whom such prescribing may be appropriate but who were not excluded from the Partnership's antipsychotics quality measure.
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The health professional experience of using antipsychotic medication for dementia in care homes: A study using grounded theory and focussing on inappropriate prescribing

TL;DR: Positive perceptions based on past experiences with antipsychotics should be challenged through future interventions that tackle inappropriate prescribing, for example using behaviour change techniques to better highlight adverse consequences of prescribing.
Journal ArticleDOI

Polypharmacy in Assisted Living and Impact on Clinical Outcomes.

TL;DR: Investigation of age, gender, race, setting, multi-morbidity, and cognitive status will help guide deprescribing so that medication management does not harm older adults physically or cause unnecessary financial burden.
References
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Journal ArticleDOI

Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory

TL;DR: A brief questionnaire form of the NPI (NPI-Q), intended for use in routine clinical practice, is developed and cross-validated in 60 Alzheimer's patients, providing a brief, reliable, informant-based assessment of neuropsychiatric symptoms and associated caregiver distress.
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Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials.

TL;DR: Small statistical effect sizes on symptom rating scales support the evidence for the efficacy of aripiprazole and risperidone.
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The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease.

TL;DR: Evidence suggests that risperidone and olanzapine are useful in reducing aggression and ris peridone reduces psychosis, but both are associated with serious adverse cerebrovascular events and extrapyramidal symptoms.
Journal ArticleDOI

A Systematic Review and Meta‐Analysis of Placebo‐Controlled Antidepressant Studies in People with Depression and Dementia

TL;DR: The objective is to determine the efficacy of antidepressants in people with depression and dementia and to establish a protocol for evaluating the safety and effectiveness of these medications.
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