scispace - formally typeset
Patent

Pyrrolacetic amides having antiinflammatory activity

TLDR
In this paper, N-monosubstituted and N,N-disubstitized amides of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid, which are active as antiinflammatory, analgesic, antipyretic, antisecretive and antitussive agents, are disclosed.
Abstract
N-monosubstituted and N,N-disubstituted amides of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid, which are active as antiinflammatory, analgesic, antipyretic, antisecretive and antitussive agents, are disclosed. These amides are prepared by reacting an amine with an activated derivative of the 1-methyl-5-p-toluoylpyrrole-2-acetic acid of formula ##STR1## wherein X is an activating group suitable for promoting the formation of an amide bond.

read more

Citations
More filters
Patent

Wound and therapy compress and dressing

TL;DR: In this paper, a fluid-permeable shell, a flexible backing fastened to the shell to define an enclosure, and a hydrophilic zeolite fill granules loosely contained within the enclosure.
Patent

Use of Amtolmetin Guacil as an anti-inflammatory agent, which also inhibits gastric secretion

TL;DR: The use of amtolmetin guacyl without gastrolesive activity and which, unlike other known non-steroidal anti-inflammatory drugs (NSAIDs) inhibits the gastric secretion stimulated with the three physiologic agents histamine, acetylcholine and gastrin is disclosed.
Patent

Moist heat therapy compress

TL;DR: In this article, a fluid-permeable shell, a flexible backing fastened to the shell to define an enclosure, and hydrophilic zeolite fill granules loosely contained within the enclosure are used for therapeutic treatment of a treated body part.
Patent

Method for counteracting blood platelet aggregation in a patient in need thereof

TL;DR: A method for counteracting platelet aggregation in a patient in need of a treatment of pain and inflammation, comprising administering (on an empty stomach) an amount of 2methoxyphenyl-1-methyl-5p-methylbenzoyl-pyrrol-2-acetamido acetate (known also as amtolmetin guacyl and indicated in the present description also as MED 15) is described in this article.
Patent

Method for treating an inflammatory pathological condition

TL;DR: In this paper, a method for treating an inflammatory pathological condition in a patient in need thereof, comprising administering on empty stomach an anti-inflammatory effective amount of 2-methoxyphenyl-1-methyl-5p-methylbenzoyl-pyrrol-2-acetamido acetate (known also as amtolmetin guacyl and indicated in the present description also as MED 15).
References
More filters
Patent

Aroyl substituted pyrroles

TL;DR: In this article, the authors describe the class of 5-AROYL-PYRROLE ALKANOIC ACIDS and CORRESPONDING ACID DERIVATIVES as "Useful as ANTI-INFLAMMATORY AGENTS and as SYNTHETIC INTEMEDIATE".
Patent

Nonsteroidal compounds as anti-inflammatory and analgesic agents

TL;DR: In this paper, 5-Aroyl-4-RO-, 5-Aroyl-4 -RO, 5-ARoyl 4-RSO 2, and 5-Pyrryl-carbonyl-pyrrole alkanoic acid have been prepared via hydrolysis of a precursor-ester after high temperature decarboxylation.
Patent

Process for preparing alkyl, aroyl substitute pyrrole-2-acetates

TL;DR: In this paper, the class of 5-aroyl-pyrrole alkanoic acids and corresponding acid derivatives thereof useful as anti-inflammatory agents and as synthetic intermediates is defined.
Patent

A novel ester of the 1-methyl-5-p-toluoylpyrrolyl-2-acetic acid having antiinflammatory, mucolytic and antitussive properties, process for its preparation and pharmaceutical compositions containing them

TL;DR: In this article, a 1-methyl-5-p-toluoylpyrrole-2-acetic acid guaiacyl ester, which possesses antiinflammatory, antipyretic, mucolytic and antitussive properties, is disclosed.
Patent

Retainer for multi-leafed devices

TL;DR: The retainer device as discussed by the authors is used for storage of multi-leafed devices such as magazines, pamphlets, notebooks and the like, and it can be used to store magazines, magazines, etc.