Journal ArticleDOI
Quantitative Imaging of Breast Density
TLDR
The breast consists mainly of two tissue components: fibroglandular tissue and fat, and change (increase or decrease) in MD overtime is also linked to change in cancer risk.Abstract:
The breast consists mainly of two tissue components: fibroglandular tissue and fat Fibroglandular tissue is a mixture of fibrous stroma and epithelial cells that line the ducts of the breast In mammography, fibroglandular tissue appearing bright is referred to as ‘mammographic density (MD)’ Evidence from many studies has established the role of MD as an independent risk factor of breast cancer [1-9] Change (increase or decrease) in MD overtime is also linked to change in cancer risk [10,11] Additionally, breast morphology is also associated with breast cancer risk [12,13]read more
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Journal ArticleDOI
Mammographic Density and the Risk and Detection of Breast Cancer
Norman F. Boyd,Helen Guo,Lisa J. Martin,Limei Sun,Jennifer Stone,Eve Fishell,Roberta A. Jong,Greg Hislop,Anna M. Chiarelli,Salomon Minkin,Martin J. Yaffe +10 more
TL;DR: Extensive mammographic density is strongly associated with the risk of breast cancer detected by screening or between screening tests, and a substantial fraction of breast cancers can be attributed to this risk factor.
Journal ArticleDOI
Quantitative Classification of Mammographic Densities and Breast Cancer Risk: Results From the Canadian National Breast Screening Study
Norman F. Boyd,J W Byng,R A Jong,E. Fishell,L E Little,Anthony B. Miller,Gina Lockwood,David Tritchler,Martin J. Yaffe +8 more
TL;DR: Increases in the level of breast tissue density as assessed by mammography are associated with increases in risk for breast cancer, and these results show that increases in theLevel of breast cancer risk associated with increasing mammographic density is shown.
Journal ArticleDOI
Breast patterns as an index of risk for developing breast cancer
TL;DR: A restrospective study of 7,214 patients placed into one of four groups of risk for developing carcinoma of the breast found that there was a 37 times greater incidence for those at highest risk compared to the low risk group.
Journal ArticleDOI
The quantitative analysis of mammographic densities
TL;DR: An interactive thresholding technique applied to digitized film-screen mammograms, which assesses the proportion of the mammographic image representing radiographically dense tissue, which may have a role in routine mammographic analysis for the purpose of assessing risk categories and as a tool in studies of the etiology of breast cancer.
Journal ArticleDOI
Heritability of mammographic density, a risk factor for breast cancer.
Norman F. Boyd,Gillian S. Dite,Jennifer Stone,Anoma Gunasekara,Dallas R. English,Margaret R. E. McCredie,Graham G. Giles,David Tritchler,Anna M. Chiarelli,Martin J. Yaffe,John L. Hopper +10 more
TL;DR: Results show that the population variation in the percentage of dense tissue on mammography at a given age has high heritability, which could be important for understanding the causes of the disease.