Relative Contributions of the Atrial Systole-Ventricular Systole Interval and of Patterns of Ventricular Activation to Ventricular Function during Electrical Pacing of the Dog Heart
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TLDR
In animals with heart block under conditions of right heart bypass, wherein changes in the pattern of ventricular activation were precluded during atrioventricular pacing, ventricular function deteriorated pari passu with shortening of the As-Vs interval.Abstract:
In areflexic canine right heart bypass preparations, little difference in ventricular function was observed as a result of atrial pacing, sequential atrioventricular pacing, or atrial-His bundle pacing at an appropriate atrial systole-ventricular systole (As-Vs) interval. Ventricular function was depressed during ventricular pacing and during atrioventricular pacing with an inappropriate As-Vs interval. In areflexic isovolumic left ventricle preparations, ventricular function was depressed during ventricular pacing compared to atrial pacing, and changes in the As-Vs interval during atrioventricular pacing were accompanied by changes in ventricular function only in association with changing patterns of ventricular activation. In animals with heart block under conditions of right heart bypass, wherein changes in the pattern of ventricular activation were precluded during atrioventricular pacing, ventricular function deteriorated pari passu with shortening of the As-Vs interval. These data indicate that both the temporal relation between atrial and ventricular contraction and the pattern of ventricular activation importantly influence ventricular function during cardiac pacing. The marked changes in ventricular function observed as a function of the As-Vs interval, for any given pattern of electrical activation, suggest that the As-Vs interval is the more important determinant of ventricular function during cardiac pacing.read more
Citations
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Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging.
TL;DR: Ventricular pacing causes a threefold difference in myofiber work within the left ventricular (LV) wall, which appears large enough to regard local myocardial function as an important determinant for abnormalities in perfusion, metabolism, structure and pump function during asynchronous electrical activation.
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Functional abnormalities in patients with permanent right ventricular pacing: the effect of sites of electrical stimulation.
TL;DR: This study demonstrates that preserved synchronous ventricular activation with RVOT pacing prevents the long-term deleterious effects of RVA pacing on myocardial perfusion and function in patients implanted with a permanent pacemaker.
Journal ArticleDOI
Asynchronous Electrical Activation Induces Asymmetrical Hypertrophy of the Left Ventricular Wall
M. F. M. Van Oosterhout,Frits W. Prinzen,Theo Arts,J. J. Schreuder,Ward Y. Vanagt,Jack P.M. Cleutjens,Robert S. Reneman +6 more
TL;DR: LV pressure-volume analysis showed that ventricular pacing reduced LV function to a similar extent after 15 minutes and 6 months of pacing, and local cardiac load regulates local cardiac mass of both myocytes and collagen.
Journal ArticleDOI
Relation Between the Pacing Induced Sequence of Activation and Left Ventricular Pump Function in Animals
Frits W. Prinzen,Maaike Peschar +1 more
TL;DR: Experimental findings justify continuing attention for optimizing the site(s) of ventricular pacing in patients with normal and abnormal ventricular impulse conduction, and differences in LV pump function between (combinations of) pacing sites are poorly correlated with QRS duration.
Journal ArticleDOI
Hemodynamic importance of preserving the normal sequence of ventricular activation in permanent cardiac pacing
TL;DR: In this article, the authors compared the effects of three pacing modes: AAI, preserving both normal AV synchrony and normal activation sequence, DDD, with complete ventricular capture that preserves only atrioventricular synchrony, and VVI, disrupting both, at rest and during exercise.
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