Journal ArticleDOI
Restraint-Induced Inhibition of 7,12-Dimethylbenz[a]anthracene-Induced Mammary Tumors: Relation to Stages of Tumor Development
TLDR
Experiments on the use of chronically applied restraint to reduce the number of mammary tumors developing in response to treatment of rats with 7,12-dimethylbenz[a]anthracene indicated that this inhibitory effect was largely due to restraint applied after the induction period; preinduction restraint and induction period restraint had no significant effect on tumor development.Abstract:
Experiments on the use of chronically applied restraint to reduce the number of mammary tumors developing in response to treatment of rats with 7,12-dimethylbenz[a]anthracene indicated that this inhibitory effect was largely due to restraint applied after the induction period; preinduction restraint and induction period restraint had no significant effect on tumor development. After termination of the restraint treatment, the rate at which new tumors appeared first increased and then decreased. Restraint did not affect the proportion of tumors regressing after ovariectomy.read more
Citations
More filters
Journal ArticleDOI
Restraint stress in biomedical research: A review
William P. Paré,Gary B. Glavin +1 more
TL;DR: The purpose of this review is to present a summary of the methods for, the parameters of, and known drug effects on, restraint-induced pathology.
Journal ArticleDOI
Stress, immunity and illness — a review
Barbara Dorian,Paul E. Garfinkel +1 more
TL;DR: Evidence is presented for a contribution of psychological factors to certain illnesses in which abnormalities in immunologic state are thought to be important and possible mechanisms for the stress/immune-change relationship are suggested.
Journal ArticleDOI
social Stress Influences Tumor Growth
Lawrence S. Sklar,Hymie Anisman +1 more
TL;DR: It appeared that it was the abrupt change in social conditions, rather than the isolation per se which was responsible for the exacerbation of tumorigenicity, and it was found that the animals' behavior after social change could modify this effect.
Journal ArticleDOI
Cancer, personality and stress: Prediction and prevention
TL;DR: A review of the history and present position of the theory that there exists a cancer-prone personality which succumbs more readily to cancer, and dies more quickly after contracting cancer, than other types of personality can be found in this paper.