Journal ArticleDOI
Review article: impact of night-time reflux on lifestyle - unrecognized issues in reflux disease.
TLDR
Although limited studies are available on the impact of pharmacological treatment on GERD QOL, recent findings indicate that proton pump inhibitors are more effective than H2‐receptor antagonists for the improvement of overall QOL.Abstract:
Gastro-oesophageal reflux disease (GERD), manifesting with symptoms including heartburn and regurgitation, affects people during both daytime and nocturnal hours. Night-time GERD has been reported to have a greater impact on a patient's life than daytime GERD due to prolonged oesophageal acid exposure time per reflux episode. To further understand this issue, it is important to implement quality of life (QOL) measures. QOL studies are becoming increasingly important to physicians in making clinical decisions, and generic and disease-specific health-related QOL (HRQL) tools have been developed to measure a wide variety of topics. There are currently no universally accepted guidelines on how to best measure HRQL in GERD patients. It is important to note that these surveys may not yield accurate results because many GERD sufferers may feel that their symptoms are not serious enough to seek treatment. Some surveys include the GERD-HRQL assessment, the Short Form Health Survey (SF-36), and the Gallup survey. When compared with daytime GERD patients, night-time GERD patients may suffer from sleep deprivation, which in turn leads to physical and emotional problems and a poor overall QOL. Studies indicate that the prevalence and impact of night-time heartburn have been underestimated and that adequate treatment of symptoms is often not achieved. In addition, GERD greatly affects work productivity and leads to a significant economic burden on society. Although limited studies are available on the impact of pharmacological treatment on GERD QOL, recent findings indicate that proton pump inhibitors are more effective than H(2)-receptor antagonists for the improvement of overall QOL.read more
Citations
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Journal ArticleDOI
Effects of gastroesophageal reflux disease on sleep and outcomes.
TL;DR: Nighttime GERD symptoms are associated with interruption of sleep induction and maintenance and result in considerable economic burden and reduction in HRQOL.
Journal ArticleDOI
Morbidity associated with sleep disorders in primary care: a longitudinal cohort study.
TL;DR: In this article, a population-based cohort study with nested case-control analysis was conducted in adults using the U.K. General Practice Research Database to assess demographics, comorbid characteristics, and health outcomes in patients with sleep disorders.
Journal ArticleDOI
Methotrexate Hepatotoxicity in Patients with Rheumatoid Arthritis
TL;DR: The prevalence of biopsy proven BE and CLE in Northern India was 2.38% and 14.81%, respectively in patients with symptoms of GERD, and the results of MB directed biopsies were similar to conventional biopsie in detecting SIM.
Journal ArticleDOI
Addition of a H2 receptor antagonist to PPI improves acid control and decreases nocturnal acid breakthrough.
TL;DR: The addition of a bedtime H2RA reduces the percentage time of the intragastric pH<4 and also NAB and should be considered as adjunct therapy in whom greater suppression of gastric acid control is considered desirable.
Journal ArticleDOI
Prediction of response to PPI therapy and factors influencing treatment outcome in patients with GORD: a prospective pragmatic trial using pantoprazole.
TL;DR: Poorer treatment responses were associated with non-erosive reflux disease, female gender, lower BMI, anxiety and concurrent irritable bowel syndrome symptoms before treatment, and no association was found with age, Helicobacter pylori status or oesophagitis grade.
References
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Journal ArticleDOI
Prevalence and clinical spectrum of gastroesophageal reflux : a population-based study in Olmsted County, Minnesota
TL;DR: Symptoms of reflux are common among white men and women who are 25-74 years of age and heartburn and acid regurgitation are significantly associated with chest pain, dysphagia, dyspepsia, and globus sensation.
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Symptomatic gastroesophageal reflux: Incidence and precipitating factors
TL;DR: Fried foods, “spicy” foods, and alcohol were the most common precipitating factors and age, sex, or hospitalization did not significantly affect incidence.
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Reliability and validity of the gastrointestinal symptom rating scale in patients with gastroesophageal reflux disease
TL;DR: The GSRS is a useful patient-rated symptom scale for evaluating the outcomes of treatment for GERD and has good reliability and construct validity and the GSRS scales discriminate by GERD symptom severity and are responsive to treatment.
Journal ArticleDOI
The impact of gastroesophageal reflux disease on health-related quality of life.
TL;DR: In this article, the authors reported that patients with Gastroesophageal reflux disease (GERD) experience decrements in health-related quality of life compared with the general population.
Journal ArticleDOI
Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association
TL;DR: Nighttime heartburn occurs in a large majority of adults with GERD, resulting in sleeping difficulties and impaired next-day function and the expected result from implemented therapy for heartburn is not achieved.