Journal ArticleDOI
Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock
N. B. Vedder,Hal G. Bingham +1 more
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This article is published in Plastic and Reconstructive Surgery.The article was published on 1990-09-01. It has received 193 citations till now. The article focuses on the topics: Shock (circulatory) & Resuscitation.read more
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Reperfusion injury and reactive oxygen species: The evolution of a concept.
D. Neil Granger,Peter R. Kvietys +1 more
TL;DR: The possibility that multiple ROS sources contribute to reperfusion injury in most tissues is supported by evidence demonstrating that redox-signaling enables ROS produced by one enzymatic source to activate and enhance ROS production by a second source.
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The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion
D. Neil Granger,Paul Kubes +1 more
TL;DR: The pathophysiological significance of the microvascular responses to inflammation are discussed in terms of adhesion‐directed strategies for the treatment of different cardiovascular diseases and circulatory disorders.
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Transfusion-related immunomodulation (TRIM): An update
TL;DR: This review categorizes the available randomized controlled trials based on the inference(s) that they permit about possible mediators of TRIM, and examines the strength of the evidence available for relying on WBC reduction or autologous transfusion to prevent TRIM effects.
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Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts.
TL;DR: Despite the substantial progress in understanding of mechanisms of inflammatory liver injury during the last decade, more research is necessary to better understand the role of ROS in acute liver inflammation and to develop clinically applicable therapeutic strategies that selectively target the detrimental effects of oxidant stress without compromising the vital function ofros in host defense.
Journal ArticleDOI
Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil
TL;DR: Therapeutic options for limiting ischaemia reperfusion injury include inhibition of oxygen radical formation, pharmacological prevention of neutrophil activation and chemotaxis, and also the use of monoclonal antibodies which prevent neutrophIL‐endothelial adhesion, a prerequisite for injury.