Kenji Inaba

TL;DR: In this article, the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1 :1:2 ratio was evaluated.

Abstract: Eukaryotic cells are able to discriminate between native and non‐native polypeptides, selectively transporting the former to their final destinations. Secretory proteins are scrutinized at the endoplasmic reticulum (ER)–Golgi interface. Recent findings reveal novel features of the underlying molecular mechanisms, with several chaperone networks cooperating in assisting the maturation of complex proteins and being selectively induced to match changing synthetic demands. ‘Public’ and ‘private’ chaperones, some of which enriched in specializes subregions, operate for most or selected substrates, respectively. Moreover, sequential checkpoints are distributed along the early secretory pathway, allowing efficiency and fidelity in protein secretion.

TL;DR: Preventable or potentially preventable deaths are rare but do occur at an academic Level I trauma center and delay in treatment and error in judgment are the leading causes of preventable and potentially Preventable deaths.

TL;DR: Resuscitative endovascular balloon occlusion of the aorta has emerged as a viable alternative to open AO in centers that have developed this capability in patients requiring AO.

TL;DR: ROTEM provided rapid and accurate detection of hyperfibrinolysis in severely injured trauma patients and helped identify patients more severely injured than expected.