Journal ArticleDOI
Salt and Hypertension: Going to the Heart of the Matter
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This article is published in JAMA Internal Medicine.The article was published on 2001-02-26. It has received 16 citations till now. The article focuses on the topics: Heart disease.read more
Citations
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Journal ArticleDOI
Experimental evidence for blood pressure-independent vascular effects of high sodium diet.
TL;DR: Experimental evidence is needed to convince the scientific community that lifelong high sodium intake expedites cardiovascular aging and reduces life expectancy independently of its effect on BP.
Journal ArticleDOI
High sodium intake increases vascular superoxide formation and promotes atherosclerosis in apolipoprotein E-deficient mice.
TL;DR: A detrimental role for high salt intake in the development of atherosclerosis is suggested and the importance of increased oxidative stress in the pathogenesis salt‐induced vascular damage is underscored.
Journal ArticleDOI
Time-Course and Mechanisms of Restored Vascular Relaxation by Reduced Salt Intake and Angiotensin II Infusion in Rats Fed a High-Salt Diet
TL;DR: Returning to a LS diet for 2 weeks or chronic 3‐day ANG II infusion restores the mechanisms that normally mediate cerebral vascular relaxation, regardless of the duration of exposure to a HS diet.
The Role of Vascular Biology, Nutrition and Nutraceuticals in the Prevention and Treatment of Hypertension
Mark C. Houston,Vascular Biology +1 more
TL;DR: Optimal nutrition, nutraceutical supplements, vitamins, antioxidants, minerals, weight loss, exercise, smoking cessation and judicious restriction of alcohol and caffeine as well as other lifestyle modifications can prevent, delay the development of hypertension.
Journal ArticleDOI
Reduced angiotensin II levels cause generalized vascular dysfunction via oxidant stress in hamster cheek pouch arterioles.
Jessica R. C. Priestley,Matthew Buelow,Scott T. McEwen,Brian D. Weinberg,Melanie Delaney,Sarah F. Balus,Carlyn Hoeppner,Lynn A Dondlinger,Julian H. Lombard +8 more
TL;DR: It is indicated that sustained exposure to low levels of circulating ANG II leads to widespread dysfunction in endothelium-dependent and independent vascular relaxation mechanisms in cheek pouch arterioles by increasing vascular oxidant stress, but does not potentiate O2- or ANG II-induced constriction of arteriole in the distal microcirculation of normotensive hamsters.
References
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Journal ArticleDOI
Salt Sensitivity of Blood Pressure in Humans
TL;DR: This review surveys the characteristics of subjects identified as salt sensitive and salt resistant by different investigators from demographic and physiological perspectives to find out whether they are salt sensitive or salt resistant.
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The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension
TL;DR: The "sALT-sensitive" patients retained more sodium on the high-sodium diet than did the patients who were not sensitive to salt ("nonsalt-sensitive"); accordingly, sodium induced more weight gain in the salt-sensitive patients.
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Salt Sensitivity, Pulse Pressure, and Death in Normal and Hypertensive Humans
TL;DR: Long-term follow-up of normotensive salt-sensitive subjects in whom assessment of salt sensitivity of blood pressure was performed as long as 27 years ago provides unique evidence of a relationship between salt sensitivity and mortality that is independent of elevated blood pressure.
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Sodium sensitivity and cardiovascular events in patients with essential hypertension
Atsushi Morimoto,Takashi Uzu,Takashi Fujii,Masataka Nishimura,Setsuko Kuroda,Satoko Nakamura,Takashi Inenaga,Genjiro Kimura +7 more
TL;DR: Cardiovascular events occurred more frequently in patients with sodium-sensitive hypertension, and Cox's proportional-hazards model identified sodium sensitivity, mean arterial pressure, and smoking as independent cardiovascular risk factors.
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Efficacy and variability of the antiproteinuric effect of ace inhibition by lisinopril
TL;DR: The antiproteinuric effect of the ACE inhibitor lisinopril appears to be dose and time related, and is strongly dependent on dietary sodium restriction, whereas it does not depend on initial proteinuria, BP, or GFR.