Book ChapterDOI
Sites and Mechanisms of the Conversion of Angiotensin I to II
Edgar Haber,Suzanne Oparil,Geoffrey W. Tregear +2 more
- pp 563-569
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The article was published on 1972-01-01. It has received 2 citations till now. The article focuses on the topics: Renin–angiotensin system.read more
Citations
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Journal ArticleDOI
Angiotensin I converting enzyme.
TL;DR: Although ACE was first considered to be a carboxypeptidase-type enzyme, its actions go beyond cleaving dipep-tides from the free C-terminal end of peptide substrates, some of the basic properties of this enzyme remain unexplained.
Journal ArticleDOI
Conversion of angiotensin I to angiotensin II.
TL;DR: In addition to inactivating hypotensive peptides and activating a hypertensive one in the systemic circulation, the enzyme may affect organ functions by hydrolyzing peptides that are formed and released locally.
References
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Journal ArticleDOI
Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects
TL;DR: Renin activity increased with Na restriction, was significantly higher on upright activity during both normal and restricted Na intake, and was most markedly elevated following the diuretic.
Journal ArticleDOI
Conversion of angiotensin I to angiotensin II.
K. K. F. Ng,John R. Vane +1 more
TL;DR: Results obtained with the blood bathed organ technique indicate that angiotensin I is converted rapidly to angiotENSin II in the pulmonary circulation and not by an enzyme in the blood.
Journal ArticleDOI
The existence of two forms of hypertensin.
TL;DR: Two types of hypertensin have been demonstrated by means of counter-current distribution and a highly purified preparation containing horse hypertensins I and II caused an elevation of blood pressure when injected into human beings.
Journal ArticleDOI
Fate of Angiotensin I in the Circulation
K. K. F. Ng,John R. Vane +1 more
TL;DR: The results of the blood-bathed organ technique do not support hypotheses which suggest a completely intra-renal role for the renin–angiotensin system.
Journal ArticleDOI