Some quantitative uses of drug antagonists
O. Arunlakshana,H. O. Schild +1 more
TLDR
Various applications of pAx measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law, and a new measure, pAh, is introduced to express the activity of unsurmountable antagonists.Abstract:
Various applications of pAx measurements are discussed based on the hypothesis that drugs and drug antagonists compete for receptors according to the mass law. Examples are given illustrating the use of pAx measurements to identify agonists which act on the same receptors and to compare the receptors of different tissues. Tests of competitive and noncompetitive antagonism are considered in relation to the antagonisms acetylcholine-atropine, histamine-atropine and acetylcholine-cinchonidine. A new measure, pAh, is introduced to express the activity of unsurmountable antagonists.read more
Citations
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Definition and antagonism of histamine H 2 -receptors.
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Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
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G Protein-Coupled Receptor Allosterism and Complexing
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References
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Journal ArticleDOI
Definition and antagonism of histamine H 2 -receptors.
TL;DR: H2-receptor antagonist, a new group of drugs, may help to unravel the physiology of histamine and gastrin.
Journal ArticleDOI
pA, a new scale for the measurement of drug antagonism
TL;DR: This is the first of a set of three papers in the Journal that were to transform the study of drug antagonism and Schild proposed and validated a new measure of antagonist action, pA, and showed how pAx measurements could provide a reproducible and statistically satisfactory index of the effectiveness of an antagonist action.
Journal Article
Electrochemical aspects of physiological and pharmacological action in excitable cells. I. The resting cell and its alteration by extrinsic factors.
Journal ArticleDOI
The Use of Chemical Potentials as Indices of Toxicity
TL;DR: A number of investigation have been published in which attempts are made to correlate the chemical or physical properties of substances with the intensity of their toxic action as mentioned in this paper, where the experiments consisted in the determination of the molar concentrations of the compounds which produced equi-toxic on a selected organism.
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The pharmacology of vascular smooth muscle.
TL;DR: As one of the part of book categories, pharmacology of vascular smooth muscle always becomes the most wanted book.