Spectrophotometric Determination of Metronidazole by Prior Reduction and Subsequent Diazotisation and Coupling with N-(1-naphthyl)ethylenediamine-Application to Pharmaceutical Preparations
TLDR
In this article, a simple, rapid and sensitive spectrophotometric method for the determination of microgram amounts of metronidazole (MZ) has been proposed, based on the reduction of METRONIDAZole with iron metal and hydrochloric acid followed by diazotisation and coupling with N-(1-naphthyl)ethylenediamine in acidic medium to give a pinkish-red colored azo dye which has maximum absorption at 503 nm.Abstract:
A simple, rapid and sensitive spectrophotometric method for the determination of microgram amounts of metronidazole (MZ) has been proposed. The method is based on the reduction of metronidazole with iron metal and hydrochloric acid followed by diazotisation and coupling with N-(1-naphthyl)ethylenediamine in acidic medium to give a pinkish-red colored azo dye which has maximum absorption at 503 nm. Beer ' s law is obeyed in the concentration range of 20-500 µg of metronidazole in a final volume of 25 ml, i.e., 0.8-20 ppm, with a molar absorptivity of 4.673×10 3 l.mol -1 . cm -1 and Sandell's sensitivity index of 0.0366 µg.cm -2 , a relative error of – 1.73 to +1.58% and relative standard deviation of ±0.47to ±1.32 %, depending on the concentration level. The method has been applied successfully to the determination of metronidazole in pharmaceutical preparations.read more
Citations
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Journal ArticleDOI
Charge Transfer Spectrophotometric Determination of Metronidazole in Pharmaceutical Formulations by Normal and Reverse Flow Injection Analysis Coupled with Solid-Phase Reactor Containing Immobilized FePO4
TL;DR: In this article, two flow injection methods were developed for the estimation of metronidazole (MRZ) in pharmaceutical formulations, which were based on charge transfer reaction between metol (N-methyl-p-aminophenol sulfate) as a I€-acceptor and reduced MRZ as an n-donor to produce a blue colored chargetransfer complex.
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References
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Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode.
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Journal ArticleDOI
Spectrophotometric determination of metronidazole and tinidazole in pharmaceutical preparations.
TL;DR: Sensitive and simple spectrophotometric methods for the determination of metronidazole (MNZ) and tinidazoles (TNZ) in either pure form or in its pharmaceutical formulations compare favourably with those of official methods.