Journal ArticleDOI
Spectrum of invasive pulmonary aspergillosis in immunocompetent patients with chronic obstructive pulmonary disease.
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TLDR
Retrospective review of all cultures that grew Aspergillus species from bronchoscopic specimens showed no false-positive results, and this procedure proved to be the most useful maneuver in making the diagnosis of invasive pulmonary aspergillosis.Abstract:
Invasive pulmonary aspergillosis is a well-recognized complication in immunocompromised patients, especially those with neutropenia. We report four cases of invasive pulmonary aspergillosis in patients whose main underlying disease was chronic obstructive pulmonary disease (COPD). Two patients had an acute fatal course, one had chronic necrotizing pulmonary aspergillosis ending in an acute fatal course, and the other had a semiacute disease that responded to amphotericin B. Autopsy on three patients showed invasive pulmonary aspergillosis in both lungs, and tissue invasion was documented by transbronchial biopsy in the patient who survived. Retrospective review of all cultures that grew Aspergillus species from bronchoscopic specimens showed no false-positive results, and this procedure proved to be the most useful maneuver in making the diagnosis. Invasive pulmonary aspergillosis should be in the differential diagnosis in patients with COPD and unexplained pulmonary infiltrates.read more
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Journal ArticleDOI
Chronic cavitary and fibrosing pulmonary and pleural aspergillosis: case series, proposed nomenclature change, and review.
TL;DR: Indicators of good long-term medical outcomes were mild symptoms, thin-walled quiescent cavities, residual pleural fibrosis, and normal inflammatory markers.
Journal ArticleDOI
Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease
TL;DR: In chronic obstructive pulmonary disease patients, invasive pulmonary aspergillosis currently carries a very poor prognosis and could perhaps be improved by more rapid diagnosis and prompt therapy with voriconazole.
Journal ArticleDOI
Aspergillus Airway Colonization and Invasive Disease After Lung Transplantation
Barbara C. Cahill,Jonathan R. Hibbs,Kay Savik,Billie A. Juni,Beth M. Dosland,Cheryl Edin-Stibbe,Marshall I. Hertz +6 more
TL;DR: A trial of empiric anti-Aspergillus therapy limited to the first 6 months posttransplant may be warranted, as Bronchoscopy with cytologic examination and fungal culture are not sensitive or timely predictors of invasive disease.
Journal ArticleDOI
Chronic Necrotizing Pulmonary Aspergillosis : Approach to Management
TL;DR: The experience with 6 patients and the current literature to update the approach to the diagnosis and treatment of chronic necrotizing pulmonary aspergillosis suggest itraconazole has emerged as a better initial therapy because of its documented efficacy and minimal toxicity.
Journal ArticleDOI
Disseminated aspergillosis in intensive care unit patients: an autopsy study.
George Dimopoulos,Michael Piagnerelli,Jacques Berré,Brahim Eddafali,Isabelle Salmon,Jean Louis Vincent +5 more
TL;DR: The rapidly fatal outcome after ICU admission suggests that colonization with Aspergillus can occur beforeICU admission, and COPD patients treated with corticosteroids and presenting with pulmonary infection should be considered at risk for disseminated aspergillosis.