Subchondral bone changes in patients with early degenerative joint disease.
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TLDR
There was no apparent difference in energy absorption among the bone plugs of the normal, the moderate, and the markedly altered cartilage groups, and these changes were not age related.Abstract:
The relationship between early degeneration of articular cartilage and the energyabsorbing abilities of its subchondral bony bed was studied in specimens obtained at autopsy from the knees of 43 male patients. Subchondral bone plugs from patients whose cartilage had only mild mucopolysaccharide loss absorbed relatively less energy on impact than the normals. There was no apparent difference in energy absorption among the bone plugs of the normal, the moderate, and the markedly altered cartilage groups. These changes were not age related.read more
Citations
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Bone remodelling in osteoarthritis.
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TL;DR: The apparent paradoxical observations that OA is associated with both increased remodelling and osteopenia, as well as decreased remodlling and sclerosis, are consistent with the spatial and temporal separation of these processes during joint degeneration.
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Response of joints to impact loading, III: relationship between trabecular microfractures and cartilage degeneration
Eric L. Radin,Howard G. Parker,James W. Pugh,Robert S. Steinberg,Igor L. Paul,Robert M. Rose +5 more
TL;DR: The knee joints of adult rabbits were subjected to daily one hour intervals of impulsive loading equivalent to their body weight at 60 cpm and developed changes in their knee joints consistent with those of degenerative joint disease.
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Role of mechanical factors in pathogenesis of primary osteoarthritis
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Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes
Guangyi Li,Guangyi Li,Ji-Min Yin,Junjie Gao,Tak Sum Cheng,Nathan J. Pavlos,Changqing Zhang,Ming H. Zheng +7 more
TL;DR: Basic features of the osteochondral junction, which comprises subchondral bone and articular cartilage, are summarized and a hypothetical model for the pathogenesis of OA is proposed.
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Relation of Dietary Intake and Serum Levels of Vitamin D to Progression of Osteoarthritis of the Knee among Participants in the Framingham Study
Timothy E. McAlindon,David T. Felson,Yuqing Zhang,Marian T. Hannan,Piran Aliabadi,Barbara N. Weissman,David Rush,Peter W.F. Wilson,Paul F. Jacques +8 more
TL;DR: The hypothesis that the relative deficiency of vitamin D, as determined by dietary intake and serum levels, predisposes patients to progression of osteoarthritis of the knee is investigated.
References
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Journal ArticleDOI
The permeability of articular cartilage
TL;DR: It is shown that the permeability of cartilage is the same in necropsy specimens as in the living animal and it may be inferred from this fact that the nutrition of Cartilage is partly dependent on joint movement.
Journal ArticleDOI
Cancellous bone: its strength and changes with aging and an evaluation of some methods for measuring its mineral content.
James K. Weaver,John Chalmers +1 more
Abstract: A study of the compressive failure strength and mineral content of cancellous bone was performed. The matrial was obtained from 150 selected autopsies. Exclusion of thirteen of the selected cadavera on clinical or histological grounds left 137 cadavera for review: seventy-two male and sixty-five fem
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A comparison of the dynamic force transmitting properties of subchondral bone and articular cartilage
TL;DR: It is highly likely, from the evidence presented, that alterations in the quality of the subchondral bone could have a profound effect on the ability of a subchONDral bone-articular cartilage system to withstand compressive dynamic forces.
Journal ArticleDOI
Does cartilage compliance reduce skeletal impact loads?. the relative force‐attenuating properties of articular cartilage, synovial fluid, periarticular soft tissues and bone
Eric L. Radin,I L Paul,I L Paul +2 more
TL;DR: The contention that the integrity of bone could well be important in prolonging joint life is supported, as the ability of synovial fluid, supporting bone and periarticular soft tissues to provide this compliance and attenuate peak forces might spare the articular cartilage and prevent wear.
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