Patent
Substance library containing bicyclic imidazo-5-yl-amines and/or bicyclic imidazo-3-yl-amines
Gerlach Matthias,Corinna Maul +1 more
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TLDR
In this article, a substance library containing bicyclic imidazo-5-yl-amines and/or bicyclic IMIDazo-3-yl -amines of general formula (I) or (II) was described, and the use of substances from this substance library for producing a medicament used to treat pain.Abstract:
The invention relates to a substance library containing bicyclic imidazo-5-yl-amines and/or bicyclic imidazo-3-yl-amines of general formula (I) or (II), to a method for producing this substance library, and to the use of substances from this substance library for producing a medicament used to treat pain.read more
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Patent
Inhibitors of prenyl-protein transferase
S. Jane deSolms,Anthony W. Shaw +1 more
TL;DR: In this article, a peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and pre-nylation of the oncogene protein Ras are presented.
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Sirtuin modulating compounds
TL;DR: A compound A) of the formula: or its pharmaceutically acceptable salt, wherein R19 is selected from: in which: each Z10, Z11, Z12 and Z13 is independently selected from N, CR20 or CR1 '; and each Z14, Z15 and Z16 are N or NR 1 '; zero to an R20 is a solubilizing group; and zero to a R1 'is optionally substituted linear or branched C1-C3 alkyl; each R20 was independently selecting from H or a
Patent
Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
Kevin S. Currie,Robert W. Desimone,Scott A. Mitchell,Douglas A. Pippin,James W. Darrow,Xiaobing Qian,Mark Velleca,Dapeng Qian +7 more
TL;DR: In this article, a method for determining the presence of tyrosine kinase activity in a sample, comprising contacting the sample with a compound or form thereof of Formula (I-a) under conditions that permit detection of Btk activity, detecting a level of B-cell activity in the sample, and therefrom determining whether or not the presence or absence of BKt activity is present.
Patent
Imidazo(1,2-a)pyrazin-8-ylamines, method of making, and method of use thereof
TL;DR: In this article, a novel composition comprises a compound of Formula 1 the pharmaceutically acceptable salts, hydrates, solvates, crystal forms, diastereomers, prodrugs or mixtures thereof.
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Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
TL;DR: In this paper, a method for determining the presence of tyrosine kinase activity in a sample, comprising contacting the sample with a compound or form thereof of Formula I under conditions that permit detection of Btk activity, detecting a level of BKA activity in the sample, and therefrom determining whether or not BKA is present or absent.
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Journal ArticleDOI
A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles
Hugues Bienaymé,Kamel Bouzid +1 more
TL;DR: The principle of chemical ligation of reactive partners (see reaction scheme) has been employed to find a new, highly efficient synthesis of fused 3-aminoimidazoles.
Journal ArticleDOI
Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation
TL;DR: A three-component condensation reaction between 2-aminopyridine, an aldehyde and an isonitrile catalyzed by scandium triflate affords derivatives of 3-aminoimidazo[1,2-a]pyridine; aminopyrazine reacts similarly.