Chi B. Vu

TL;DR: These compounds bind to the SIRT1 enzyme–peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates and improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver.

TL;DR: A compound A) of the formula: or its pharmaceutically acceptable salt, wherein R19 is selected from: in which: each Z10, Z11, Z12 and Z13 is independently selected from N, CR20 or CR1 '; and each Z14, Z15 and Z16 are N or NR 1 '; zero to an R20 is a solubilizing group; and zero to a R1 'is optionally substituted linear or branched C1-C3 alkyl; each R20 was independently selecting from H or a

TL;DR: A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD(+)-dependent deacetylase SIRT1, a potential new therapeutic target to treat various metabolic disorders.

TL;DR: In this paper, the sirtuin-modulating compounds of formula (I) and methods of use thereof are presented for increasing the lifespan of a cell and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemo therapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and or -disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and flushing

TL;DR: The identification and SAR of a series of oxazolo[4,5-b]pyridines as novel small molecule activators of SIRT1 which are structurally unrelated to and more potent than resveratrol are described.