Journal ArticleDOI
Suzuki‐Miyaura cross–coupling reaction in water: facile synthesis of (hetero) aryl uracil bases using potassiumorganotrifluoroborates under microwave irradiation.
Bhaskaran Savitha,Ayyiliath M. Sajith,Eeda Koti Reddy,C.S. Ananda Kumar,M. Syed Ali Padusha +4 more
- Vol. 1, Iss: 15, pp 4721-4725
Reads0
Chats0
TLDR
A comparative study of the cross-coupling reaction of this chloro uracil analogue with different nucleophilic organoboron source revealed the superior reactivity of (hetero) aryl potassiumorganotrifluoroborates in water under microwave irradiation.Abstract:
In this paper, we report the use of (hetero) aryl potassiumorganotrifluoroborate salts as versatile nucleophilic organoboron reagents in the Suzuki-Miyaura cross-coupling reaction of an electron rich 6-chloro 3-methyl uracil in water under microwave irradiation. A comparative study of the cross-coupling reaction of this chloro uracil analogue with different nucleophilic organoboron source revealed the superior reactivity of (hetero) aryl potassiumorganotrifluoroborates in water under microwave irradiation. Diversely functionalised (hetero) aryl uracil bases, which are known possess a wide range of applications in chemical biology, were efficiently synthesized using this optimised protocol.read more
Citations
More filters
Journal ArticleDOI
Microwave-Assisted Palladium-Catalyzed Cross-Coupling Reactions: Generation of Carbon–Carbon Bond
Kifah S. M. Salih,Younis Baqi +1 more
TL;DR: In this article, the authors mainly focus on the recent advances and applications of palladium catalyzed cross-coupling carbon-carbon bond formation under microwave technology, and they mainly apply the microwave irradiation technique to carbon-C bond formation.
Journal ArticleDOI
Synthesis of Arylated Nucleobases by Visible Light Photoredox Catalysis
TL;DR: The method provides a simple, metal-free alternative for the synthesis of biologically interesting arylated heterocycles under mild conditions and allows the room temperature conversion of brominated and chlorinated nucleobase precursors as starting materials.
Journal ArticleDOI
Application of Palladium Based Precatalytic Systems in the Suzuki-Miyaura Cross-Coupling Reactions of Chloro- Heterocycles
Journal ArticleDOI
New Trends in C-C Cross-Coupling Reactions: The Use of Unconventional Conditions.
TL;DR: The present review comprises literature from 2015 onward covering the implementation of unconventional methodologies in carbon–carbon (C–C) cross-coupling reactions that embodies a variety of strategies, from the use of alternative energy sources to solvent- free and green media protocols.
Journal ArticleDOI
NMI/MsCl‐Mediated Amide Bond Formation of Aminopyrazines and Aryl/Heteroaryl Carboxylic Acids: Synthesis of Biologically Relevant Pyrazine Carboxamides.
Nagaraja Reddy Gangarapu,Nagaraja Reddy Gangarapu,Eeda Koti Reddy,Ayyiliath M. Sajith,Shivaraj Yellappa,Kothapalli Bannoth Chandrasekhar +5 more
References
More filters
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
5-Fluorouracil: mechanisms of action and clinical strategies
TL;DR: This work has shown that novel genes identified in DNA microarray profiling have the potential to identify novel genes that are involved in mediating resistance to 5-FU, and these genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to5-FU-based chemotherapy.
Journal ArticleDOI
Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998
TL;DR: The palladium-catalyzed cross-coupling reaction between organoboron compounds and organic halides or triflates provides a powerful and general methodology for the formation of carbon-carbon bonds as discussed by the authors.
Journal ArticleDOI
A new stereospecific cross-coupling by the palladium-catalyzed reaction of 1-alkenylboranes with 1-alkenyl or 1-alkynyl halides
TL;DR: In this article, the representative (E)-1-alkenyldisiamylboranes and 1-alkenyl-1,3,2-benzodioxaboroles readily obtainable via hydroboration of 1 -alkynes react with (1) halides or (1)-alkynyl halides in the presence of a catalytic amount of tetrakis(triphenylphosphine)palladium and base to give corresponding conjugated (E-dienes or (E-)enynes with high regio-and
Journal ArticleDOI
Stereoselective synthesis of arylated (E)-alkenes by the reaction of alk-1-enylboranes with aryl halides in the presence of palladium catalyst
Norio Miyaura,Akira Suzuki +1 more
TL;DR: The reaction of aryl halides with alk-l-enylboranes, readily obtainable via monohydroboration of acetylenes, provides a conveninet new method for stereoselective synthesis of E-alkenes in high yields; these reactions are effectively catalysed by tetrakis(triphenylphosphine)palladium and bases such as sodium ethoxide as discussed by the authors.