Journal ArticleDOI
Symptomatic recurrences of carcinoma of the rectum and sigmoid. The influence of radiotherapy on the quality of life.
TLDR
One hundred forty-three patients irradiated for locoregional recurrences after curative surgery for cancer of the rectum and sigmoid were studied retrospectively and symptom-free period was calculated as percent of the overall survival.Abstract:
One hundred forty-three patients irradiated for locoregional recurrences after curative surgery for cancer of the rectum and sigmoid were studied retrospectively. An analysis was made of the symptomatic response and survival in the total series and in three subgroups treated with different dose levels (40 Gy or lower, between 40 and 50 Gy, 50 Gy or higher). The symptom-free period was calculated as percent of the overall survival. Symptomatic control was obtained in 80.4 percent of the cases, and the crude patient survival rate was 17.5 percent at two years. No significant difference was found in the three subgroups treated with different dose levels. The cumulative time/patient asymptomatic periods in the total series and in the three subgroups were 31.5, 30.2, 31.8, and 31.9 percent respectively, of the survival period.read more
Citations
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Journal ArticleDOI
Surgical management of locally recurrent rectal cancer
Peter M. Sagar,John H. Pemberton +1 more
TL;DR: The surgical management of locally recurrent rectal cancer may involve major procedures and is not for the faint‐hearted; nevertheless, such treatment is preferable to chemotherapy and radiotherapy; the latter will fail over a period of months during which the patient is likely to experience intractable pain.
Journal Article
PET studies of fluorodeoxyglucose metabolism in patients with recurrent colorectal tumors receiving radiotherapy.
Uwe Haberkorn,Ludwig G. Strauss,A. Dimitrakopoulou,R. Engenhart,Franz Oberdorfer,Hermann Ostertag,J. Romahn,G. van Kaick +7 more
TL;DR: It is concluded that an observation interval longer than 6 mo may more effectively detect residual tumor activity and that PET is more sensitive than the measurements of CEA plasma levels for tumor recurrence.
Journal ArticleDOI
Impact of Surgical and Pathologic Variables in Rectal Cancer: A United States Community and Cooperative Group Report
Luca Stocchi,Heidi Nelson,D. J. Sargent,Michael J. O’Connell,Joel E. Tepper,James E. Krook,Robert Beart +6 more
TL;DR: Moderate variability in outcomes among surgeons was detected in this high-risk population of patients with stage II/III rectal cancer, and efforts to improve surgical results will require changes in reporting practices to allow for more accurate assessment of the quality of surgery.
Journal ArticleDOI
Pelvic exenteration with en bloc iliac vessel resection for lateral pelvic wall involvement.
TL;DR: Careful preoperative radiologic assessment and a multidisciplinary approach are paramount to achieving clear margins and this surgical approach to lateral pelvic sidewall involvement is safe and feasible.
Journal ArticleDOI
Patterns of pelvic invasion are prognostic in the treatment of locally recurrent rectal cancer.
TL;DR: The aim of this study was to elucidate prognostic risk factors after resection of recurrent cancer in local recurrence of rectal cancer after curative resection.
References
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Journal ArticleDOI
Areas of failure found at reoperation (second or symptomatic look) following "curative surgery" for adenocarcinoma of the rectum. Clinicopathologic correlation and implications for adjuvant therapy.
Leonard L. Gunderson,Henry Sosin +1 more
TL;DR: Postoperative irradiation may be a logical adjuvant in view of the high percentage of local‐regional failures and the ability to identify subgroups of patients at highest risk for such failure.
Journal ArticleDOI
Patterns of pelvic recurrence following definitive resections of rectal cancer.
Stephen J. Pilipshen,Martin L. Heilweil,Stuart H. Q. Quan,Stephen S. Sternberg,Warren E. Enker +4 more
TL;DR: The timing and predominance of pelvic failure in rectal cancer with its own treatment‐related morbidity and overall dismal survival outcome justifies organized multidisciplinary efforts to prevent such failure and prospective trials of comprehensive follow-up programs to evaluate improved cure rates or palliation.
Journal ArticleDOI
Detection and treatment of recurrent cancer of the colon and rectum
TL;DR: A series of 177 patients with recurrent colorectal cancer treated at the Massachusetts General Hospital is examined retrospectively, finding evidence that even the symptomatic patient may be well palliated or even cured by surgical resection of the recurrence or palliative therapy.
Journal ArticleDOI
Patterns of recurrence following curative resection alone for adenocarcinoma of the rectum and sigmoid colon
TL;DR: Through five years local recurrence without clinical evidence of distant metastasis was the most common cause of death and need for adjuvant radiation therapy is discussed.
Journal Article
Analysis of recurrence patterns following curative resection for carcinoma of the colon and rectum.
TL;DR: From this analysis, a schema involving patterns of failure as related to primary site and stage within the colon, rectum and sigmoid were developed.
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Areas of failure found at reoperation (second or symptomatic look) following "curative surgery" for adenocarcinoma of the rectum. Clinicopathologic correlation and implications for adjuvant therapy.
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