Synthesis and Aldose Reductase-Inhibitory Activity of Benzo[b]furan Derivatives Possessing a Carboxymethylsulfamoyl Group
Reads0
Chats0
TLDR
Among the test compounds, the compounds having a carboxymethylsulfamoyl group at the 3- or 4-position exhibited the greatest inhibitory potency, and structure-activity trends of the tested compounds are discussed.Abstract:
Various benzo[b]futran derivatives with a carboxymethylsulfamoyl group were prepared and evaluated for aldose reductase-inhibitory potency. Most of the compounds displayed significant inhibitory activities (IC50, 10-8-10-7M). Among the test compounds, the compounds having a carboxymethylsulfamoyl group at the 3- or 4-position exhibited the greatest inhibitory potency. Structure-activity trends of the tested compounds are discussed.read more
Citations
More filters
Journal ArticleDOI
Methods for the synthesis of benzofuran derivatives (review)
M. G. Kadieva,É. T. Oganesyan +1 more
TL;DR: In this article, the authors reviewed data published in the last 15 years on methods for the construction of the benzofuran ring and discussed the mechanisms of the reactions and their use in the synthesis of biologically active substances.
Reference EntryDOI
The Vilsmeier Reaction of Fully Conjugated Carbocycles and Heterocycles
TL;DR: The Vilsmeier reaction has been the subject of many review articles of varying scope and length as mentioned in this paper, and the most commonly used reagent, that made from DMF and phosphoryl chloride, is an equilibrium mixture of iminium salts, which is usually hydrolyzed to the aromatic aldehyde.
Journal ArticleDOI
Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity.
Kumiko Ando,Eriko Tsuji,Yuko Ando,Noriko Kuwata,Jun-ichi Kunitomo,Masayuki Yamashita,Shunsaku Ohta,Shigekatsu Kohno,Yoshitaka Ohishi +8 more
TL;DR: The 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3 position were synthesized starting with 3-aminobenzos[b]-furans as discussed by the authors.
Journal ArticleDOI
An efficient synthesis of benzofurans and their application in the preparation of natural products of the genus Calea
TL;DR: In this paper, the intramolecular cyclization of the β-substituted olefins methyl 2-aryloxy-3-dimethylaminopropenoates 3a−3f catalyzed by Lewis acids leads to a short and novel synthesis of benzofurans 2a−2f.
Journal ArticleDOI
Synthesis and structure–activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: A novel series of 5-HT2C receptor antagonists
TL;DR: A novel series of 1H-indole-3-carboxylic acid pyridine- 3-ylamides were synthesized and identified to show high affinity and selectivity for 5-HT(2C) receptor.
References
More filters
Book
Advanced Organic Chemistry: Reactions, Mechanisms, and Structure
TL;DR: Localized Chemical bonding Delocalized Chemical Bonding Bonding Weaker than Covalent Stereochemistry Carbocations, Carbanions, Free Radicals, Carbenes and Nitrenes Mechanisms and Methods of Determining them Photochemistry Acids and Bases Effects of Structure on Reactivity Aliphatic Nucleophilic Substitution Aromatic Electrophilic Substitutes Aliphatically Electrophilic Substitution Free-Radical Substitution Addition to Carbon-Carbon Multiple Bonds Adding to Carbon Hetero Multiple Bonds Eliminations Rearrangements Ox
Book
Experiments in organic chemistry
TL;DR: The first steps in safety practices in the organic chemistry laboratory are outlined in this paper and guidelines for notebooks are discussed. But safety practices are not discussed in detail in this paper.