Patent
Synthesis method of natural product cephalotaxine
TLDR
In this article, a new synthesis route for cephalotaxine was proposed, which has the advantages of unique and novel design of the synthesis route, mild conditions of the reaction process, high speed, few side reactions, simplicity in operation, and realization of cheap and easily available raw materials and great reduction of synthesis cost due to conventional chemical reagents.Abstract:
The invention discloses a synthesis method of a natural product cephalotaxine. The purpose of the invention is to provide a brand new synthesis route. Sodium cyclopentadienylide used as an initial rawmaterial undergoes key reaction steps such as a hydroboration oxidation reaction, an iodide ion induced N heterocyclic ring construction reaction and a palladium-catalyzed coupling ring closing reaction to finally achieve formalized synthesis of the natural product cephalotaxine. The method has the advantages of unique and novel design of the synthesis route, mild conditions of the reaction process, high speed, few side reactions, simplicity in operation, and realization of cheap and easily available raw materials and great reduction of the synthesis cost due to conventional chemical reagentsutilized in the route.read more
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